Best poster presentation award, 25th Hellenic Hematology Congress

Best poster presentation award
25th Hellenic Hematology Congress, Hellenic Hematology Society

ANALYSIS OF POTENTIAL MECHANISMS OF AGGRESSIVENESS
IN CHRONIC LYMPHOCYTIC LEUKEMIA STEREOTYPED SUBSET 1 CASES

Recipients of the distinction
Stavroula Ntoufa, Νikos Papakonstantinou, Tzeni Karamanli, Chrysi Galigalidou, Sofia Griva, Achilles Anagnostopoulos, Chrysoula Belessi, Kostas Stamatopoulos

Description
Chronic Lymphocytic Leukemia (CLL) stereotyped subset 1 cases are characterized by the expression of stereotyped immunoglobulins, of the IgMD isotype and is a model of aggressive clinical course. Overall, in this study we analyzed various signaling mechanisms that could influence the behavior of leukemic cells probably interpreting the aggressive clinical course of stereotyped subset 1 (SS1) cases. The analysis revealed no signaling differences between SS1 cases and other patients with similar IGHV gene mutational status (U-CLL). Our results indicate that the clinical aggressiveness of SS1 is formed both by exogenous stimulation (immune signaling) as by endogenous mechanisms (e.g. tumorigenic lesions).

Contact Info

Stavroula Ntoufa
E-mail: sntoufa@certh.gr
Tel: (0030) 2311 257525