«Arkagathos Gouttas» Prize (Award), 25th Hellenic Ηematology Congress
«Arkagathos Gouttas» Prize (Award), 25th Congress of the Hellenic Society of Hematology
Recipients of the distinction
Nikos Papakonstantinou, Stavroula Ntoufa, Liza Chartomatsidou, Andreas Agathangelidis, Tzeni Karamanli, Achilles Anagnostopoulos, Paolo Ghia, Richard Rosenquist, Chrysoula Belessi, Kostas Stamatopoulos
OVEREXPRESSION OF THE HISTONE METHYLTRANSFERASE ΕΖΗ2 IN CHRONIC LYMPHOCYTIC LEUKEMIA CONFERS PROTECTION FROM APOPTOSIS AND IS LINKED TO CLINICAL AGGRESSIVENESS
EZH2 is the enzymatic subunit of the polycomb repressive complex 2 (PRC2), which induces gene repression through trimethylation of histone H3 at lysine 27 (H3K27me3). EZH2 over-expression has been reported in a broad range of both hematopoietic and solid malignancies and associated with poor prognosis. In this study, we demonstrated that EZH2 overexpression is correlated with prolonged CLL cell survival and that pharmacological inhibition of EZH2 catalytic activity leads to apoptosis, highlighting a crucial role for EZH2 in CLL cell survival. On these grounds, EZH2 emerges as a novel therapeutic target for specific subgroups of CLL.
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