Health Translational Research – Publications

2017

  1. Agorastos T, Chatzistamatiou K, Moysiadis T, Kaufmann AM, Skenderi A, Lekka I, Koch I, Soutschek E, Boecher O, Kilintzis V, Angelidou S, Katsiki E, Hagemann I, Boschetti Gruetzmacher E, Tsertanidou A, Angelis L, Maglaveras N, Jansen-Duerr P. Human papillomavirus E7 protein detection as a method of triage to colposcopy of HPV positive women, in comparison to genotyping and cytology. Final results of the PIPAVIR study. Int J Cancer. 2017 Aug 1;141(3):519-530. doi:10.1002/ijc.30761. Epub 2017 May 15. PubMed PMID: 28470689.
  2. Chatzistamatiou K, Moysiadis T, Angelis E, Kaufmann A, Skenderi A, Jansen-Duerr P, Lekka I, Kilintzis V, Angelidou S, Katsiki E, Hagemann I, Tsertanidou A, Koch I, Boecher O, Soutschek E, Maglaveras N, Agorastos T. Diagnostic accuracy of high-risk HPV DNA genotyping for primary cervical cancer screening and triage of HPV-positive women, compared to cytology: preliminary results of the PIPAVIR study. Arch Gynecol Obstet. 2017 May;295(5):1247-1257. doi: 10.1007/s00404-017-4324-x. Epub 2017 Mar 23. PubMed PMID: 28337594.
  3. Ten Hacken E, Gounari M, Back JW, Shimanovskaya E, Scarfo L, Kim E, Burks J, Ponzoni M, Ramirez GA, Wierda WG, Estrov Z, Keating MJ, Ferrajoli A, Stamatopoulos K, Ghia P, Burger JA. Calreticulin as a novel B cell receptor antigen in chronic lymphocytic leukemia. Haematologica. 2017 Jul 27. pii: haematol.2017.169102. doi: 10.3324/haematol.2017.169102. [Epub ahead of print] PubMed PMID: 28751563.
  4. Rawstron AC, Ssemaganda A, de Tute R, Doughty C, Newton D, Vardi A, Evans PAS, Stamatopoulos K, Owen RG, Lightfoot T, Wakeham K, Karabarinde A, Asiki G, Newton R. Monoclonal B-cell lymphocytosis in a hospital-based UK population and a rural Ugandan population: a cross-sectional study. Lancet Haematol. 2017 Jul;4(7):e334-e340. doi: 10.1016/S2352-3026(16)30192-2. PubMed PMID: 28668191; PubMed Central PMCID: PMC5493519.
  5. Minici C, Gounari M, Übelhart R, Scarfò L, Dühren-von Minden M, Schneider D, Tasdogan A, Alkhatib A, Agathangelidis A, Ntoufa S, Chiorazzi N, Jumaa H, Stamatopoulos K, Ghia P, Degano M. Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia. Nat Commun. 2017 Jun 9;8:15746. doi: 10.1038/ncomms15746. PubMed PMID: 28598442; PubMed Central PMCID: PMC5472768.
  6. Sutton LA, Hadzidimitriou A, Baliakas P, Agathangelidis A, Langerak AW, Stilgenbauer S, Pospisilova S, Davis Z, Forconi F, Davi F, Ghia P, Rosenquist R, Stamatopoulos K; European Research Initiative on CLL (ERIC). Immunoglobulin genes in chronic lymphocytic leukemia: key to understanding the disease and improving risk stratification. Haematologica. 2017 Jun;102(6):968-971. doi: 10.3324/haematol.2017.165605. PubMed PMID: 28566340; PubMed Central PMCID: PMC5451327.
  7. Xochelli A, Baliakas P, Kavakiotis I, Agathangelidis A, Sutton LA, Minga E, Ntoufa S, Tausch E, Yan XJ, Shanafelt T, Plevova K, Boudjogra M, Rossi D, Davis Z, Navarro A, Sandberg Y, Vojdeman FJ, Scarfo L, Stavroyianni N, Sudarikov A, Veronese S, Tzenou T, Karan-Djurasevic T, Catherwood M, Kienle D, Chatzouli M, Facco M, Bahlo J, Pott C, Pedersen LB, Mansouri L, Smedby KE, Chu CC, Giudicelli V, Lefranc MP, Panagiotidis P, Juliusson G, Anagnostopoulos A, Vlahavas I, Antic D, Trentin L, Montillo M, Niemann C, Döhner H, Langerak AW, Pospisilova S, Hallek M, Campo E, Chiorazzi N, Maglaveras N, Oscier D, Gaidano G, Jelinek DF, Stilgenbauer S, Chouvarda I, Darzentas N, Belessi C, Davi F, Hadzidimitriou A, Rosenquist R, Ghia P, Stamatopoulos K. Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes. Clin Cancer Res. 2017 May 23. doi: 10.1158/1078-0432.CCR-16-3100. [Epub ahead of print] PubMed PMID: 28536306.
  8. Mastrodemou S, Stalika E, Vardi A, Gemenetzi K, Spanoudakis M, Karypidou M, Mavroudi I, Hadzidimitriou A, Stavropoulos-Giokas C, Papadaki HA, Stamatopoulos K. Cytotoxic T cells in chronic idiopathic neutropenia express restricted antigen receptors. Leuk Lymphoma. 2017 Dec;58(12):2926-2933. doi: 10.1080/10428194.2017.1324154. Epub 2017 May 23. PubMed PMID: 28535087.
  9. Pouliou E, Xochelli A, Kanellis G, Stalika E, Sutton LA, Navarro A, Agathangelidis A, Dimosthenous K, Anagnostopoulos A, Patsouris E, Korkolopoulou P, Sundstrom C, Ghia P, Ponzoni M, Sander B, Campo E, Rosenquist R,Hadzidimitriou A, Stamatopoulos K, Papadaki T. Numerous Ontogenetic Roads to Mantle Cell Lymphoma: Immunogenetic and Immunohistochemical Evidence. Am J Pathol. 2017 Jul;187(7):1454-1458. doi: 10.1016/j.ajpath.2017.02.017. Epub 2017 Apr 28. PubMed PMID: 28457696.
  10. Rosenquist R, Ghia P, Hadzidimitriou A, Sutton LA, Agathangelidis A, Baliakas P, Darzentas N, Giudicelli V, Lefranc MP, Langerak AW, Belessi C, Davi F, Stamatopoulos K. Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: updated ERIC recommendations. Leukemia. 2017 Jul;31(7):1477-1481. doi: 10.1038/leu.2017.125. Epub 2017 Apr 25. PubMed PMID: 28439111; PubMed Central PMCID: PMC5508071.
  11. Langerak AW, Brüggemann M, Davi F, Darzentas N, van Dongen JJM, Gonzalez D, Cazzaniga G, Giudicelli V, Lefranc MP, Giraud M, Macintyre EA, Hummel M, Pott C, Groenen PJTA, Stamatopoulos K; EuroClonality-NGS Consortium. High-Throughput Immunogenetics for Clinical and Research Applications in Immunohematology: Potential and Challenges. J Immunol. 2017 May 15;198(10):3765-3774. doi: 10.4049/jimmunol.1602050. Epub 2017 Apr 17. PubMed PMID: 28416603.
  12. Ghia P, Nadel B, Sander B, Stamatopoulos K, Stevenson FK. Early stages in the ontogeny of small B-cell lymphomas: genetics and microenvironment. J Intern Med. 2017 Apr 10. doi: 10.1111/joim.12608. [Epub ahead of print] PubMed PMID: 28393412.
  13. Xochelli A, Oscier D, Stamatopoulos K. Clonal B-cell lymphocytosis of marginal zone origin. Best Pract Res Clin Haematol. 2017 Mar – Jun;30(1-2):77-83. doi: 10.1016/j.beha.2016.08.028. Epub 2016 Nov 4. Review. PubMed PMID: 28288720.
  14. Vilia MG, Fonte E, Veliz Rodriguez T, Tocchetti M, Ranghetti P, Scarfò L, Papakonstantinou N, Ntoufa S, Stamatopoulos K, Ghia P, Muzio M. The inhibitory receptor toll interleukin-1R 8 (TIR8/IL-1R8/SIGIRR) is downregulated in chronic lymphocytic leukemia. Leuk Lymphoma. 2017 Oct;58(10):2419-2425. doi: 10.1080/10428194.2017.1295142. Epub 2017 Feb 28. PubMed PMID: 28278705.
  15. Catera R, Liu Y, Gao C, Yan XJ, Magli A, Allen SL, Kolitz JE, Rai KR, Chu CC, Feizi T, Stamatopoulos K, Chiorazzi N. Binding of CLL subset 4 B-cell receptor immunoglobulins to viable human memory B lymphocytes requires a distinctive IGKV somatic mutation. Mol Med. 2017 Jan 12;23. doi: 10.2119/molmed.2017.00003. [Epub ahead of print] PubMed PMID: 28097289; PubMed Central PMCID: PMC5364113.
  16. Curiel-Olmo S, Mondéjar R, Almaraz C, Mollejo M, Cereceda L, Marès R, Derdak S, Campos-Martín Y, Batlle A, González de Villambrosía S, Gut M, Blanc J, Traverse-Glehen A, Verney A, Baseggio L, Camacho FI, Wotherspoon A, Stamatopoulos K, Xochelli A, Papadaki T, Kanellis G, Ponzoni M, García-Cosío M, Vaqué JP, Beltrán S, Gut I, Piris MA, Martínez N. Splenic diffuse red pulp small B-cell lymphoma displays increased expression of cyclin D3 and recurrent CCND3 mutations. Blood. 2017 Feb 23;129(8):1042-1045. doi: 10.1182/blood-2016-11-751024. Epub 2017 Jan 9. PubMed PMID: 28069605.
  17. Vardi A, Vlachonikola E, Karypidou M, Stalika E, Bikos V, Gemenetzi K, Maramis C, Siorenta A, Anagnostopoulos A, Pospisilova S, Maglaveras N, Chouvarda I, Stamatopoulos K, Hadzidimitriou A. Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elements. Leukemia. 2017 Jul;31(7):1555-1561. doi: 10.1038/leu.2016.362. Epub 2016 Nov 25. PubMed PMID: 27904140.
  18. Young E, Noerenberg D, Mansouri L, Ljungström V, Frick M, Sutton LA, Blakemore SJ, Galan-Sousa J, Plevova K, Baliakas P, Rossi D, Clifford R, Roos-Weil D, Navrkalova V, Dörken B, Schmitt CA, Smedby KE, Juliusson G, Giacopelli B, Blachly JS, Belessi C, Panagiotidis P, Chiorazzi N, Davi F, Langerak AW, Oscier D, Schuh A, Gaidano G, Ghia P, Xu W, Fan L, Bernard OA, Nguyen-Khac F, Rassenti L, Li J, Kipps TJ, Stamatopoulos K, Pospisilova S, Zenz T, Oakes CC, Strefford JC, Rosenquist R, Damm F. EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia. Leukemia. 2017 Jul;31(7):1547-1554. doi: 10.1038/leu.2016.359. Epub 2016 Nov 28. PubMed PMID: 27890934.
  19. Wren D, Walker BA, Brüggemann M, Catherwood MA, Pott C, Stamatopoulos K, Langerak AW, Gonzalez D; EuroClonality-NGS consortium. Comprehensive translocation and clonality detection in lymphoproliferative disorders by next-generation sequencing. Haematologica. 2017 Feb;102(2):e57-e60. doi: 10.3324/haematol.2016.155424. Epub 2016 Oct 20. PubMed PMID: 27846615; PubMed Central PMCID: PMC5286955.
  20. Blanco G, Puiggros A, Baliakas P, Athanasiadou A, García-Malo M, Collado R, Xochelli A, Rodríguez-Rivera M, Ortega M, Calasanz MJ, Luño E, Vargas M, Grau J, Martínez-Laperche C, Valiente A, Cervera J, Anagnostopoulos A, Gimeno E, Abella E, Stalika E, Hernández-Rivas JM, Ortuño FJ, Robles D, Ferrer A, Ivars D, González M, Bosch F, Abrisqueta P, Stamatopoulos K, Espinet B. Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations. Oncotarget. 2016 Dec 6;7(49):80916-80924. doi: 10.18632/oncotarget.13106. PubMed PMID: 27821812; PubMed Central PMCID: PMC5348364.
  21. Stamatopoulos K, Agathangelidis A, Rosenquist R, Ghia P. Antigen receptor stereotypy in chronic lymphocytic leukemia. Leukemia. 2017 Feb;31(2):282-291. doi: 10.1038/leu.2016.322. Epub 2016 Nov 4. Review. PubMed PMID: 27811850.
  22. Parker H, Rose-Zerilli MJ, Larrayoz M, Clifford R, Edelmann J, Blakemore S, Gibson J, Wang J, Ljungström V, Wojdacz TK, Chaplin T, Roghanian A, Davis Z, Parker A, Tausch E, Ntoufa S, Ramos S, Robbe P, Alsolami R, Steele AJ, Packham G, Rodríguez-Vicente AE, Brown L, McNicholl F, Forconi F, Pettitt A, Hillmen P, Dyer M, Cragg MS, Chelala C, Oakes CC, Rosenquist R, Stamatopoulos K, Stilgenbauer S, Knight S, Schuh A, Oscier DG, Strefford JC. Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia. Leukemia. 2016 Nov;30(11):2179-2186. doi: 10.1038/leu.2016.134. Epub 2016 May 20. PubMed PMID: 27282254; PubMed Central PMCID: PMC5023049.
  23. Gemenetzi K, Galigalidou C, Vlachonikola E, Stalika E, Xochelli A, Baliakas P, Karypidou M, Touloumenidou T, Minga E, Douka V, Iskas M, Athanasiadou A, Makris A, Stavroyianni N, Anagnostopoulos A, Hadzidimitriou A, Stamatopoulos K. Tp53 gene p72R polymorphism in chronic lymphocytic leukemia: incidence and clinical significance amongst cases with unmutated immunoglobulin receptors. Leuk Lymphoma. 2017 Mar;58(3):726-728. doi: 10.1080/10428194.2016.1211276. Epub 2016 Aug 9. PubMed PMID: 27686405.

2016

  1. Chatzistamatiou K, Moysiadis T, Moschaki V, Panteleris N, Agorastos T. Comparison of cytology, HPV DNA testing and HPV 16/18 genotyping alone or combined targeting to the more balanced methodology for cervical cancer screening. Gynecol Oncol. 2016 Jul;142(1):120-7. doi: 10.1016/j.ygyno.2016.04.027. Epub 2016 May 8. PubMed PMID: 27126005.
  2. Mansouri L, Noerenberg D, Young E, Mylonas E, Abdulla M, Frick M, Asmar F, Ljungström V, Schneider M, Yoshida K, Skaftason A, Pandzic T, Gonzalez B, Tasidou A, Waldhueter N, Rivas-Delgado A, Angelopoulou M, Ziepert M, Arends CM, Couronné L, Lenze D, Baldus CD, Bastard C, Okosun J, Fitzgibbon J, Dörken B, Drexler HG, Roos-Weil D, Schmitt CA, Munch-Petersen HD, Zenz T, Hansmann ML, Strefford JC, Enblad G, Bernard OA, Ralfkiaer E, Erlanson M, Korkolopoulou P, Hultdin M, Papadaki T, Grønbæk K, Lopez-Guillermo A, Ogawa S, Küppers R, Stamatopoulos K, Stavroyianni N, Kanellis G, Rosenwald A, Campo E, Amini RM, Ott G, Vassilakopoulos TP, Hummel M, Rosenquist R, Damm F. Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma. Blood. 2016 Dec 8;128(23):2666-2670. Epub 2016 Sep 26. PubMed PMID: 27670424.
  3. Rosenquist R, Rosenwald A, Du MQ, Gaidano G, Groenen P, Wotherspoon A, Ghia P, Gaulard P, Campo E, Stamatopoulos K; European Research Initiative on CLL (ERIC) and the European Association for Haematopathology (EAHP). Clinical impact of recurrently mutated genes on lymphoma diagnostics: state-of-the-art and beyond. Haematologica. 2016 Sep;101(9):1002-9. doi: 10.3324/haematol.2015.134510. Review. PubMed PMID: 27582569; PubMed Central PMCID: PMC5060016.
  4. Rosenquist R, Stamatopoulos K. B-cell malignancies: All roads lead to NF-κB activation. Semin Cancer Biol. 2016 Aug;39:1-2. doi: 10.1016/j.semcancer.2016.08.003. Epub 2016 Aug 18. PubMed PMID: 27546288.
  5. Mansouri L, Papakonstantinou N, Ntoufa S, Stamatopoulos K, Rosenquist R. NF-κB activation in chronic lymphocytic leukemia: A point of convergence of external triggers and intrinsic lesions. Semin Cancer Biol. 2016 Aug;39:40-8. doi: 10.1016/j.semcancer.2016.07.005. Epub 2016 Aug 1. Review. PubMed PMID: 27491692.
  6. Navrkalova V, Young E, Baliakas P, Radova L, Sutton LA, Plevova K, Mansouri L, Ljungström V, Ntoufa S, Davis Z, Juliusson G, Smedby KE, Belessi C, Panagiotidis P, Touloumenidou T, Davi F, Langerak AW, Ghia P, Strefford JC, Oscier D, Mayer J, Stamatopoulos K, Pospisilova S, Rosenquist R, Trbusek M. ATM mutations in major stereotyped subsets of chronic lymphocytic leukemia: enrichment in subset #2 is associated with markedly short telomeres. Haematologica. 2016 Sep;101(9):e369-73. doi: 10.3324/haematol.2016.142968. Epub 2016 Jun 16. PubMed PMID: 27479817; PubMed Central PMCID: PMC5060033.
  7. Ntoufa S, Vilia MG, Stamatopoulos K, Ghia P, Muzio M. Toll-like receptors signaling: A complex network for NF-κB activation in B-cell lymphoid malignancies. Semin Cancer Biol. 2016 Aug;39:15-25. doi: 10.1016/j.semcancer.2016.07.001. Epub 2016 Jul 9. Review. PubMed PMID: 27402288.
  8. Kavakiotis I, Xochelli A, Agathangelidis A, Tsoumakas G, Maglaveras N, Stamatopoulos K, Hadzidimitriou A, Vlahavas I, Chouvarda I. Integrating multiple immunogenetic data sources for feature extraction and mining somatic hypermutation patterns: the case of “towards analysis” in chronic lymphocytic leukaemia. BMC Bioinformatics. 2016 Jun 6;17 Suppl 5:173. doi: 10.1186/s12859-016-1044-3. PubMed PMID: 27295298; PubMed Central PMCID: PMC4905615.
  9. Sutton LA, Young E, Baliakas P, Hadzidimitriou A, Moysiadis T, Plevova K, Rossi D, Kminkova J, Stalika E, Pedersen LB, Malcikova J, Agathangelidis A, Davis Z, Mansouri L, Scarfò L, Boudjoghra M, Navarro A, Muggen AF, Yan XJ, Nguyen-Khac F, Larrayoz M, Panagiotidis P, Chiorazzi N, Niemann CU, Belessi C, Campo E, Strefford JC, Langerak AW, Oscier D, Gaidano G, Pospisilova S, Davi F, Ghia P, Stamatopoulos K, Rosenquist R; ERIC, the European Research Initiative on CLL. Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors. Haematologica. 2016 Aug;101(8):959-67. doi: 10.3324/haematol.2016.141812. Epub 2016 May 19. PubMed PMID: 27198719; PubMed Central PMCID: PMC4967575.
  10. Papakonstantinou N, Ntoufa S, Chartomatsidou E, Kotta K, Agathangelidis A, Giassafaki L, Karamanli T, Bele P, Moysiadis T, Baliakas P, Sutton LA, Stavroyianni N, Anagnostopoulos A, Makris AM, Ghia P, Rosenquist R, Stamatopoulos K. The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia. Oncotarget. 2016 Jun 14;7(24):35946-35959. doi: 10.18632/oncotarget.9371. PubMed PMID: 27191993; PubMed Central PMCID: PMC5094974.
  11. Baliakas P, Puiggros A, Xochelli A, Sutton LA, Nguyen-Khac F, Gardiner A, Plevova K, Minga E, Hadzidimitriou A, Walewska R, McCarthy H, Ortega M, Collado R, González T, Granada I, Luño E, Kotašková J, Moysiadis T, Davis Z, Stavroyianni N, Anagnostopoulos A, Strefford JC, Pospisilova S, Davi F, Athanasiadou A, Rosenquist R, Oscier D, Espinet B, Stamatopoulos K. Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference. Haematologica. 2016 Jul;101(7):e299-302. doi: 10.3324/haematol.2015.140202. Epub 2016 Apr 21. PubMed PMID: 27102498; PubMed Central PMCID: PMC5004477.
  12. Ntoufa S, Papakonstantinou N, Apollonio B, Gounari M, Galigalidou C, Fonte E, Anagnostopoulos A, Belessi C, Muzio M, Ghia P, Stamatopoulos K. B Cell Anergy Modulated by TLR1/2 and the miR-17∼92 Cluster Underlies the Indolent Clinical Course of Chronic Lymphocytic Leukemia Stereotyped Subset #4. J Immunol. 2016 May 15;196(10):4410-7. doi: 10.4049/jimmunol.1502297. Epub 2016 Apr 8. PubMed PMID: 27059597.
  13. Pospisilova S, Sutton LA, Malcikova J, Tausch E, Rossi D, Montserrat E, Moreno C, Stamatopoulos K, Gaidano G, Rosenquist R, Ghia P; European Research Initiative on CLL (ERIC). Innovation in the prognostication of chronic lymphocytic leukemia: how far beyond TP53 gene analysis can we go? Haematologica. 2016 Mar;101(3):263-5. doi: 10.3324/haematol.2015.139246. PubMed PMID: 26928246; PubMed Central PMCID: PMC4815716.
  14. Engert A, Balduini C, Brand A, Coiffier B, Cordonnier C, Döhner H, de Wit TD, Eichinger S, Fibbe W, Green T, de Haas F, Iolascon A, Jaffredo T, Rodeghiero F, Salles G, Schuringa JJ; EHA Roadmap for European Hematology Research. The European Hematology Association Roadmap for European Hematology Research: a consensus document. Haematologica. 2016 Feb;101(2):115-208. doi: 10.3324/haematol.2015.136739. Epub 2016 Jan 27. PubMed PMID: 26819058; PubMed Central PMCID: PMC4938336.
  15. Baliakas P, Mattsson M, Stamatopoulos K, Rosenquist R. Prognostic indices in chronic lymphocytic leukaemia: where do we stand how do we proceed? J Intern Med. 2016 Apr;279(4):347-57. doi: 10.1111/joim.12455. Epub 2015 Dec 28. Review. PubMed PMID: 26709197.
  16. Ljungström V, Cortese D, Young E, Pandzic T, Mansouri L, Plevova K, Ntoufa S, Baliakas P, Clifford R, Sutton LA, Blakemore SJ, Stavroyianni N, Agathangelidis A, Rossi D, Höglund M, Kotaskova J, Juliusson G, Belessi C, Chiorazzi N, Panagiotidis P, Langerak AW, Smedby KE, Oscier D, Gaidano G, Schuh A, Davi F, Pott C, Strefford JC, Trentin L, Pospisilova S, Ghia P, Stamatopoulos K, Sjöblom T, Rosenquist R. Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations. Blood. 2016 Feb 25;127(8):1007-16. doi: 10.1182/blood-2015-10-674572. Epub 2015 Dec 16. PubMed PMID: 26675346; PubMed Central PMCID: PMC4768426.
  17. Bikos V, Karypidou M, Stalika E, Baliakas P, Xochelli A, Sutton LA, Papadopoulos G, Agathangelidis A, Papadopoulou E, Davis Z, Algara P, Kanellis G, Traverse-Glehen A, Mollejo M, Anagnostopoulos A, Ponzoni M, Gonzalez D, Pospisilova S, Matutes E, Piris MA, Papadaki T, Ghia P, Rosenquist R, Oscier D, Darzentas N, Tzovaras D, Belessi C, Hadzidimitriou A, Stamatopoulos K. An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors. Clin Cancer Res. 2016 Apr 15;22(8):2032-40. doi: 10.1158/1078-0432.CCR-15-1170. Epub 2015 Dec 8. PubMed PMID: 26647217.
  18. Vardi A, Agathangelidis A, Stalika E, Karypidou M, Siorenta A, Anagnostopoulos A, Rosenquist R, Hadzidimitriou A, Ghia P, Sutton LA, Stamatopoulos K. Antigen Selection Shapes the T-cell Repertoire in Chronic Lymphocytic Leukemia. Clin Cancer Res. 2016 Jan 1;22(1):167-74. doi: 10.1158/1078-0432.CCR-14-3017. Epub 2015 Sep 2. PubMed PMID: 26338994.

 

2015

  1. Fonte E, Agathangelidis A, Reverberi D, Ntoufa S, Scarfò L, Ranghetti P, Cutrona G, Tedeschi A, Xochelli A, Caligaris-Cappio F, Ponzoni M, Belessi C, Davis Z, Piris MA, Oscier D, Ghia P, Stamatopoulos K, Muzio M. Toll-like receptor stimulation in splenic marginal zone lymphoma can modulate cell signaling, activation and proliferation. Haematologica. 2015 Nov;100(11):1460-8. doi: 10.3324/haematol.2014.119933. Epub 2015 Aug 20. PubMed PMID: 26294727; PubMed Central PMCID: PMC4825289.
  2. Baliakas P, Hadzidimitriou A, Agathangelidis A, Rossi D, Sutton LA, Kminkova J, Scarfo L, Pospisilova S, Gaidano G, Stamatopoulos K, Ghia P, Rosenquist R. Prognostic relevance of MYD88 mutations in CLL: the jury is still out. Blood. 2015 Aug 20;126(8):1043-4. doi: 10.1182/blood-2015-05-648634. PubMed PMID: 26294719; PubMed Central PMCID: PMC4598193
  3. Bystry V, Agathangelidis A, Bikos V, Sutton LA, Baliakas P, Hadzidimitriou A, Stamatopoulos K, Darzentas N; European Research Initiative on CLL. ARResT/AssignSubsets: a novel application for robust subclassification of chronic lymphocytic leukemia based on B cell receptor IG stereotypy. Bioinformatics. 2015 Dec 1;31(23):3844-6. doi: 10.1093/bioinformatics/btv456. Epub 2015 Aug 6. PubMed PMID: 26249808.
  4. Puente XS, Beà S, Valdés-Mas R, Villamor N, Gutiérrez-Abril J, Martín-Subero JI, Munar M, Rubio-Pérez C, Jares P, Aymerich M, Baumann T, Beekman R, Belver L, Carrio A, Castellano G, Clot G, Colado E, Colomer D, Costa D, Delgado J, Enjuanes A, Estivill X, Ferrando AA, Gelpí JL, González B, González S, González M, Gut M, Hernández-Rivas JM, López-Guerra M, Martín-García D, Navarro A, Nicolás P, Orozco M, Payer ÁR, Pinyol M, Pisano DG, Puente DA, Queirós AC, Quesada V, Romeo-Casabona CM, Royo C, Royo R, Rozman M, Russiñol N, Salaverría I, Stamatopoulos K, Stunnenberg HG, Tamborero D, Terol MJ, Valencia A, López-Bigas N, Torrents D, Gut I, López-Guillermo A, López-Otín C, Campo E. Non-coding recurrent mutations in chronic lymphocytic leukaemia. Nature. 2015 Oct 22;526(7574):519-24. doi: 10.1038/nature14666. Epub 2015 Jul 22. PubMed PMID: 26200345.
  5. Mansouri L, Sutton LA, Ljungström V, Bondza S, Arngården L, Bhoi S, Larsson J, Cortese D, Kalushkova A, Plevova K, Young E, Gunnarsson R, Falk-Sörqvist E, Lönn P, Muggen AF, Yan XJ, Sander B, Enblad G, Smedby KE, Juliusson G, Belessi C, Rung J, Chiorazzi N, Strefford JC, Langerak AW, Pospisilova S, Davi F, Hellström M, Jernberg-Wiklund H, Ghia P, Söderberg O, Stamatopoulos K, Nilsson M, Rosenquist R. Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia. J Exp Med. 2015 Jun 1;212(6):833-43. doi: 10.1084/jem.20142009. Epub 2015 May 18. PubMed PMID: 25987724; PubMed Central PMCID: PMC4451125.
  6. Gounari M, Ntoufa S, Apollonio B, Papakonstantinou N, Ponzoni M, Chu CC, Rossi D, Gaidano G, Chiorazzi N, Stamatopoulos K, Ghia P. Excessive antigen reactivity may underlie the clinical aggressiveness of chronic lymphocytic leukemia stereotyped subset #8. Blood. 2015 Jun 4;125(23):3580-7. doi: 10.1182/blood-2014-09-603217. Epub 2015 Apr 21. PubMed PMID: 25900981; PubMed Central PMCID: PMC4458798.
  7. Xochelli A, Sutton LA, Agathangelidis A, Stalika E, Karypidou M, Marantidou F, Lopez AN, Papadopoulos G, Supikova J, Groenen P, Boudjogra M, Sundstrom C, Ponzoni M, Francova HS, Anagnostopoulos A, Pospisilova S, Papadaki T, Tzovaras D, Ghia P, Pott C, Davi F, Campo E, Rosenquist R, Hadzidimitriou A, Belessi C, Stamatopoulos K. Molecular evidence for antigen drive in the natural history of mantle cell lymphoma. Am J Pathol. 2015 Jun;185(6):1740-8. doi: 10.1016/j.ajpath.2015.02.006. Epub 2015 Apr 2. PubMed PMID: 25843681.
  8. Parry M, Rose-Zerilli MJ, Ljungström V, Gibson J, Wang J, Walewska R, Parker H, Parker A, Davis Z, Gardiner A, McIver-Brown N, Kalpadakis C, Xochelli A,
  9. Anagnostopoulos A, Fazi C, de Castro DG, Dearden C, Pratt G, Rosenquist R, Ashton-Key M, Forconi F, Collins A, Ghia P, Matutes E, Pangalis G, Stamatopoulos K, Oscier D, Strefford JC. Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing. Clin Cancer Res. 2015 Sep 15;21(18):4174-4183. doi: 10.1158/1078-0432.CCR-14-2759. Epub 2015 Mar 16. PubMed PMID: 25779943; PubMed Central PMCID: PMC4490180.
  10. Moreno C, Montillo M, Panayiotidis P, Dimou M, Bloor A, Dupuis J, Schuh A, Norin S, Geisler C, Hillmen P, Doubek M, Trněný M, Obrtlikova P, Laurenti L, Stilgenbauer S, Smolej L, Ghia P, Cymbalista F, Jaeger U, Stamatopoulos K, Stavroyianni N, Carrington P, Zouabi H, Leblond V, Gomez-Garcia JC, Rubio M, Marasca R, Musuraca G, Rigacci L, Farina L, Paolini R, Pospisilova S, Kimby E, Bradley C, Montserrat E. Ofatumumab in poor-prognosis chronic lymphocytic leukemia: a phase IV, non-interventional, observational study from the European Research Initiative on Chronic Lymphocytic Leukemia. Haematologica. 2015 Apr;100(4):511-6. doi: 10.3324/haematol.2014.118158. Epub 2015 Jan 16. PubMed PMID: 25596264; PubMed Central PMCID: PMC4380724.
  11. Sutton LA, Papadopoulos G, Hadzidimitriou A, Papadopoulos S, Kostareli E, Rosenquist R, Tzovaras D, Stamatopoulos K. An entity evolving into a community: defining the common ancestor and evolutionary trajectory of chronic lymphocytic leukemia stereotyped subset #4. Mol Med. 2015 Apr 2;20:720-8. doi: 10.2119/molmed.2014.00140. PubMed PMID: 25486132; PubMed Central PMCID: PMC4398667.
  12. Sutton LA, Ljungström V, Mansouri L, Young E, Cortese D, Navrkalova V, Malcikova J, Muggen AF, Trbusek M, Panagiotidis P, Davi F, Belessi C, Langerak AW, Ghia P, Pospisilova S, Stamatopoulos K, Rosenquist R. Targeted next-generation sequencing in chronic lymphocytic leukemia: a high-throughput yet tailored approach will facilitate implementation in a clinical setting. Haematologica. 2015 Mar;100(3):370-6. doi: 10.3324/haematol.2014.109777. Epub 2014 Dec 5. PubMed PMID: 25480502; PubMed Central PMCID: PMC4349276.
  13. Xochelli A, Agathangelidis A, Kavakiotis I, Minga E, Sutton LA, Baliakas P, Chouvarda I, Giudicelli V, Vlahavas I, Maglaveras N, Bonello L, Trentin L, Tedeschi A, Panagiotidis P, Geisler C, Langerak AW, Pospisilova S, Jelinek DF, Oscier D, Chiorazzi N, Darzentas N, Davi F, Ghia P, Rosenquist R, Hadzidimitriou A, Belessi C, Lefranc MP, Stamatopoulos K. Immunoglobulin heavy variable (IGHV) genes and alleles: new entities, new names and implications for research and prognostication in chronic lymphocytic leukaemia. Immunogenetics. 2015 Jan;67(1):61-6. doi: 10.1007/s00251-014-0812-3. Epub 2014 Nov 12. PubMed PMID: 25388851.
  14. Baliakas P, Hadzidimitriou A, Sutton LA, Rossi D, Minga E, Villamor N, Larrayoz M, Kminkova J, Agathangelidis A, Davis Z, Tausch E, Stalika E, Kantorova B, Mansouri L, Scarfò L, Cortese D, Navrkalova V, Rose-Zerilli MJ, Smedby KE, Juliusson G, Anagnostopoulos A, Makris AM, Navarro A, Delgado J, Oscier D, Belessi C, Stilgenbauer S, Ghia P, Pospisilova S, Gaidano G, Campo E, Strefford JC, Stamatopoulos K, Rosenquist R; European Research Initiative on CLL (ERIC). Recurrent mutations refine prognosis in chronic lymphocytic leukemia. Leukemia. 2015 Feb;29(2):329-36. doi: 10.1038/leu.2014.196. Epub 2014 Jun 19. PubMed PMID: 24943832.
  15. Baliakas P, Strefford JC, Bikos V, Parry M, Stamatopoulos K, Oscier D. Splenic marginal-zone lymphoma: ontogeny and genetics. Leuk Lymphoma. 2015 Feb;56(2):301-10. doi: 10.3109/10428194.2014.919636. Epub 2014 Aug 19. Review. PubMed PMID: 24798744.
  16. Chatzistamatiou Κ., Moysiadis T., Moschaki V., Panteleris N., Agorastos T. :Comparison of cytology, HPV DNA testing and HPV 16/18 genotyping alone or combined targeting to the more balanced methodology for cervical cancer screening. Gynecologic Oncology 2016.
  17. Bystry V, Agathangelidis A, Bikos V, Sutton LA, Baliakas P, Hadzidimitriou A, Stamatopoulos K, Darzentas N; also on behalf of ERIC, the European Research Initiative on CLL. ARResT/AssignSubsets: a novel application for robust subclassification of chronic lymphocytic leukemia based on B cell receptor IG stereotypy. Bioinformatics. 2015 Aug 6. pii: btv456. [Epub ahead of print] PubMed PMID: 26249808.
  18. Baliakas P, Hadzidimitriou A, Agathangelidis A, Rossi D, Sutton LA, Kminkova J, Scarfo L, Pospisilova S, Gaidano G, Stamatopoulos K, Ghia P, Rosenquist R. Prognostic relevance of MYD88 mutations in CLL: the jury is still out. Blood. 2015 Aug 20;126(8):1043-4. doi: 10.1182/blood-2015-05-648634. PubMed PMID: 26294719.
  19. Fonte E, Agathangelidis A, Reverberi D, Ntoufa S, Scarfò L, Ranghetti P, Cutrona G, Tedeschi A, Xochelli A, Caligaris-Cappio F, Ponzoni M, Belessi C, Davis Z, Piris MA, Oscier D, Ghia P, Stamatopoulos K, Muzio M. TOLL-LIKE RECEPTOR STIMULATION IN SPLENIC MARGINAL ZONE LYMPHOMA CAN MODULATE CELL SIGNALING, ACTIVATION AND PROLIFERATION. Haematologica. 2015 Aug 20. pii: haematol.2014.119933. [Epub ahead of print] PubMed PMID: 26294727.
  20. Vardi A, Agathangelidis A, Stalika E, Karypidou M, Siorenta A, Anagnostopoulos A, Rosenquist R, Hadzidimitriou A, Ghia P, Sutton LA, Stamatopoulos K. ANTIGEN SELECTION SHAPES THE T-CELL REPERTOIRE IN CHRONIC LYMPHOCYTIC LEUKEMIA. Clin Cancer Res. 2015 Sep 2. pii: clincanres.3017.2014. [Epub ahead of print] PubMed PMID: 26338994.
  21. Mansouri L, Sutton LA, Ljungstrom V, Bondza S, Arngarden L, Bhoi S, Larsson J, Cortese D, Kalushkova A, Plevova K et alFunctional loss of IkappaBepsilon leads to NF-kappaB deregulation in aggressive chronic lymphocytic leukemiaJ Exp Med 2015, 212(6):833-843
  22. Puente XS, Bea S, Valdes-Mas R, Villamor N, Gutierrez-Abril J, Martin-Subero JI, Munar M, Rubio-Perez C, Jares P, Aymerich M et alNon-coding recurrent mutations in chronic lymphocytic leukaemiaNature 2015
  23. Gounari M, Ntoufa S, Apollonio B, Papakonstantinou N, Ponzoni M, Chu CC, Rossi D, Gaidano G, Chiorazzi N, Stamatopoulos K et alExcessive antigen reactivity may underlie the clinical aggressiveness of chronic lymphocytic leukemia stereotyped subset 8Blood 2015
  24. Xochelli A, Sutton LA, Agathangelidis A, Stalika E, Karypidou M, Marantidou F, Lopez AN, Papadopoulos G, Supikova J, Groenen P et al:Antigen Drive in the Natural History of Mantle Cell Lymphoma: Molecular Evidence. Am J Pathol. 2015
  25. Parry M, Rose-Zerilli MJ, Ljungström V, Gibson J, Wang J, Walewska R, Parker H, Parker AE, Davis Z, Gardiner A et al: Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing. Clin Cancer Res. 2015
  26. Baliakas P, Agathangelidis A, Hadzidimitriou A, Sutton LA, Minga E, Tsanousa A, Scarfò L, Davis Z, Yan XJ, Shanafelt T et al: Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations. Blood 2015, 125(5):856-9.
  27. Moreno C, Montillo M, Panayiotidis P, Dimou M, Bloor A, Dupuis J, Schuh A, Norin S, Geisler C, Hillmen P et al: Ofatumumab in poor-prognosis chronic lymphocytic leukemia: a Phase IV, non-interventional, observational study from the European Research Initiative on Chronic Lymphocytic Leukemia. Haematologica 2015, 100(4):511-6
  28. Sutton LA, Papadopoulos G, Hadzidimitriou A, Papadopoulos S, Kostareli E, Rosenquist R, Tzovaras D, Stamatopoulos K.  An entity evolving into a community: defining the common ancestor and evolutionary trajectory of chronic lymphocytic leukemia stereotyped subset #4. Mol Med 2015, 20(1):720-8
  29. Sutton LA, Ljungström V, Mansouri L, Young E, Cortese D, Navrkalova V, Malcikova J, Muggen AF, Trbusek M, Panagiotidis P et al: Targeted next-generation sequencing in chronic lymphocytic leukemia: a high-throughput yet tailored approach will facilitate implementation in a clinical setting. Haematologica 2015, 100(3):370-6
  30. Xochelli A, Agathangelidis A, Kavakiotis I, Minga E, Sutton LA, Baliakas P, Chouvarda I, Giudicelli V, Vlahavas I, Maglaveras N et alImmunoglobulin heavy variable (IGHV) genes and alleles: new entities, new names and implications for research and prognostication in chronic lymphocytic leukaemia.Immunogenetics 2015, 67(1):61-6
  31. Baliakas P, Hadzidimitriou A, Sutton LA, Rossi D, Minga E, Villamor N, Larrayoz M, Kminkova J, Agathangelidis A, Davis Z et alRecurrent mutations refine prognosis in chronic lymphocytic leukemiaLeukemia 2015, 29(2):329-36.

2014

  1. Baliakas P, Hadzidimitriou A, Sutton LA, Minga E, Agathangelidis A, Nichelatti M, Tsanousa A, Scardo L, Davis Z, Yan XJ et al: Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study. Lancet Haematology. 2014,1(2):74-84
  2. Agathangelidis A, Vardi A, Baliakas P, Stamatopoulos K: Stereotyped B-cell receptors in chronic lymphocytic leukemia. Leuk Lymphoma 2014, 55(10):2252-2261.
  3. Baliakas P, Iskas M, Gardiner A, Davis Z, Plevova K, Nguyen-Khac F, Malcikova J, Anagnostopoulos A, Glide S, Mould S et al: Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: a systematic reappraisal of classic cytogenetic data. Am J Hematol 2014, 89(3):249-255.
  4. Baliakas P, Strefford JC, Bikos V, Parry M, Stamatopoulos K, Oscier D: Splenic marginal-zone lymphoma: ontogeny and genetics. Leuk Lymphoma 2014:1-10.
  5. Bergh AC, Evaldsson C, Pedersen LB, Geisler C, Stamatopoulos K, Rosenquist R, Rosen A: Silenced B-cell receptor response to autoantigen in a poor-prognostic subset of chronic lymphocytic leukemia. Haematologica 2014, 99(11):1722-1730.
  6. Chatzouli M, Ntoufa S, Papakonstantinou N, Chartomatsidou E, Anagnostopoulos A, Kollia P, Ghia P, Muzio M, Stamatopoulos K, Belessi C: Heterogeneous functional effects of concomitant B cell receptor and TLR stimulation in chronic lymphocytic leukemia with mutated versus unmutated Ig genes. J Immunol 2014, 192(10):4518-4524.
  7. Gebhart J, Lechner K, Skrabs C, Sliwa T, Muldur E, Ludwig H, Nosslinger T, Vanura K, Stamatopoulos K, Simonitsch-Klupp I et al: Lupus anticoagulant and thrombosis in splenic marginal zone lymphoma. Thromb Res 2014, 134(5):980-984.
  8. Malcikova J, Stalika E, Davis Z, Plevova K, Trbusek M, Mansouri L, Scarfo L, Baliakas P, Gardiner A, Sutton LA et al: The frequency of TP53 gene defects differs between chronic lymphocytic leukaemia subgroups harbouring distinct antigen receptors. Br J Haematol 2014, 166(4):621-625.
  9. Mansouri L, Sutton LA, Ljungstrom V, Sorqvist EF, Gunnarsson R, Smedby KE, Juliusson G, Stamatopoulos K, Nilsson M, Rosenquist R: Feasibility of targeted next-generation sequencing of the TP53 and ATM genes in chronic lymphocytic leukemia. Leukemia 2014, 28(3):694-696.
  10. Stalika E, Kanellis G, Papalexandri A, Iskas M, Vrakidou E, Demonakou M, Anagnostopoulos A, Stamatopoulos K, Papadaki T: Cytotoxic T cell-mediated gastritis after rituximab treatment for gastric malt lymphoma. Leuk Lymphoma 2014, 55(3):702-705.
  11. Stalika E, Papalexandri A, Iskas M, Stavroyianni N, Kanellis G, Kotta K, Pontikoglou C, Siorenta A, Anagnostopoulos A, Papadaki H et al: Familial CD3+ T large granular lymphocyte leukemia: evidence that genetic predisposition and antigen selection promote clonal cytotoxic T-cell responses. Leuk Lymphoma 2014, 55(8):1781-1787.
  12. Sutton LA, Ljungstrom V, Mansouri L, Young E, Cortese D, Navrkalova V, Malcikova J, Muggen AF, Trbusek M, Panagiotidis P et al: Targeted next-generation sequencing in chronic lymphocytic leukemia: a high-throughput yet tailored approach will facilitate implementation within a clinical setting. Haematologica 2014.
  13. Sutton LA, Papadopoulos G, Hadzidimitriou A, Papadopoulos S, Kostareli E, Rosenquist R, Tzovaras D, Stamatopoulos K: An Entity Evolving into a Community: Defining the Common Ancestor and Evolutionary Trajectory of Chronic Lymphocytic Leukemia Stereotyped Subset #4. Mol Med 2014.
  14. Vardi A, Agathangelidis A, Sutton LA, Chatzouli M, Scarfo L, Mansouri L, Douka V, Anagnostopoulos A, Darzentas N, Rosenquist R et al: IgG-switched CLL has a distinct immunogenetic signature from the common MD variant: ontogenetic implications. Clin Cancer Res 2014, 20(2):323-330.
  15. Vardi A, Agathangelidis A, Sutton LA, Ghia P, Rosenquist R, Stamatopoulos K: Immunogenetic studies of chronic lymphocytic leukemia: revelations and speculations about ontogeny and clinical evolution. Cancer Res 2014, 74(16):4211-4216.
  16. Xochelli A, Baliakas P, Moore S, Sole F, Wickham N, Salido M, Athanasiadou A, Oscier D, Stamatopoulos K: Translocation t(2;7)(p11.2;q21.2): a rare genetic aberration associated with B-cell lymphoproliferative disorders of marginal-zone origin. Cancer Genet 2014, 207(6):281-283.
  17. Xochelli A, Kalpadakis C, Gardiner A, Baliakas P, Vassilakopoulos TP, Mould S, Davis Z, Stalika E, Kanellis G, Angelopoulou MK et al: Clonal B-cell lymphocytosis exhibiting immunophenotypic features consistent with a marginal-zone origin: is this a distinct entity? Blood 2014, 123(8):1199-1206.

2013

  1. Agathangelidis A, Ntoufa S, Stamatopoulos K: B cell receptor and antigens in CLL. Adv Exp Med Biol 2013, 792:1-24.
  2. Baliakas P, Kanellis G, Stavroyianni N, Fameli M, Anagnostopoulos A, Stamatopoulos K, Papadaki T: The role of bone marrow biopsy examination at diagnosis of chronic lymphocytic leukemia: a reappraisal. Leuk Lymphoma 2013, 54(11):2377-2384.
  3. Chigrinova E, Rinaldi A, Kwee I, Rossi D, Rancoita PM, Strefford JC, Oscier D, Stamatopoulos K, Papadaki T, Berger F et al: Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome. Blood 2013, 122(15):2673-2682.
  4. Colombo M, Cutrona G, Reverberi D, Bruno S, Ghiotto F, Tenca C, Stamatopoulos K, Hadzidimitriou A, Ceccarelli J, Salvi S et al: Expression of Ig receptors with distinctive features indicating antigen selection by marginal zone B cells from human spleen. Mol Med 2013.
  5. Darzentas N, Stamatopoulos K: The significance of stereotyped B-cell receptors in chronic lymphocytic leukemia. Hematol Oncol Clin North Am 2013, 27(2):237-250.
  6. Darzentas N, Stamatopoulos K: Stereotyped B cell receptors in B cell leukemias and lymphomas. Methods Mol Biol 2013, 971:135-148.
  7. Kanduri M, Sander B, Ntoufa S, Papakonstantinou N, Sutton LA, Stamatopoulos K, Kanduri C, Rosenquist R: A key role for EZH2 in epigenetic silencing of HOX genes in mantle cell lymphoma. Epigenetics 2013, 8(12):1280-1288.
  8. Papakonstantinou N, Ntoufa S, Chartomatsidou E, Papadopoulos G, Hatzigeorgiou A, Anagnostopoulos A, Chlichlia K, Ghia P, Muzio M, Belessi C et al: Differential microRNA profiles and their functional implications in different immunogenetic subsets of chronic lymphocytic leukemia. Mol Med 2013, 19:115-123.
  9. Papalexandri A, Stalika E, Iskas M, Karypidou M, Zerva P, Touloumenidou T, Tachynopoulou V, Batsis I, Papadaki T, Sakellari I et al: Molecular evidence for repertoire skewing of T large granular lymphocyte proliferation after allogeneic hematopoietic SCT: report of two cases. Bone Marrow Transplant 2013, 48(9):1260-1261.
  10. Rosenquist R, Davi F, Stamatopoulos K: Antigens in lymphoma development–current knowledge and future directions. Semin Cancer Biol 2013, 23(6):397-398.
  11. Strefford JC, Sutton LA, Baliakas P, Agathangelidis A, Malcikova J, Plevova K, Scarfo L, Davis Z, Stalika E, Cortese D et al: Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2. Leukemia 2013, 27(11):2196-2199.
  12. Sutton LA, Agathangelidis A, Belessi C, Darzentas N, Davi F, Ghia P, Rosenquist R, Stamatopoulos K: Antigen selection in B-cell lymphomas–tracing the evidence. Semin Cancer Biol 2013, 23(6):399-409.
  13. Sutton LA, Kostareli E, Stalika E, Tsaftaris A, Anagnostopoulos A, Darzentas N, Rosenquist R, Stamatopoulos K: Temporal dynamics of clonal evolution in chronic lymphocytic leukemia with stereotyped IGHV4-34/IGKV2-30 antigen receptors: longitudinal immunogenetic evidence. Mol Med 2013, 19:230-236.
  14. ten Hacken E, Scielzo C, Bertilaccio MT, Scarfo L, Apollonio B, Barbaglio F, Stamatopoulos K, Ponzoni M, Ghia P, Caligaris-Cappio F: Targeting the LYN/HS1 signaling axis in chronic lymphocytic leukemia. Blood 2013, 121(12):2264-2273.
  15. Vanura K, Rieder F, Kastner MT, Biebl J, Sandhofer M, Le T, Strassl R, Puchhammer-Stockl E, Perkmann T, Steininger CF et al: Chronic lymphocytic leukemia patients have a preserved cytomegalovirus-specific antibody response despite progressive hypogammaglobulinemia. PLoS One 2013, 8(10):e78925.
  16. Vardi A, Dagklis A, Scarfo L, Jelinek D, Newton D, Bennett F, Almeida J, Rodriguez-Caballero A, Allgood S, Lanasa M et al: Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL. Blood 2013, 121(22):4521-4528.

2012

  1. Agathangelidis A, Darzentas N, Hadzidimitriou A, Brochet X, Murray F, Yan XJ, Davis Z, van Gastel-Mol EJ, Tresoldi C, Chu CC et al: Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies. Blood 2012, 119(19):4467-4475.
  2. Bikos V, Darzentas N, Hadzidimitriou A, Davis Z, Hockley S, Traverse-Glehen A, Algara P, Santoro A, Gonzalez D, Mollejo M et al: Over 30% of patients with splenic marginal zone lymphoma express the same immunoglobulin heavy variable gene: ontogenetic implications. Leukemia 2012, 26(7):1638-1646.
  3. Bikos V, Stalika E, Baliakas P, Darzentas N, Davis Z, Traverse-Glehen A, Dagklis A, Kanellis G, Anagnostopoulos A, Tsaftaris A et al: Selection of antigen receptors in splenic marginal-zone lymphoma: further support from the analysis of the immunoglobulin light-chain gene repertoire. Leukemia 2012, 26(12):2567-2569.
  4. Dagklis A, Ponzoni M, Govi S, Cangi MG, Pasini E, Charlotte F, Vino A, Doglioni C, Davi F, Lossos IS et al: Immunoglobulin gene repertoire in ocular adnexal lymphomas: hints on the nature of the antigenic stimulation. Leukemia 2012, 26(4):814-821.
  5. Halldorsdottir AM, Kanduri M, Marincevic M, Mansouri L, Isaksson A, Goransson H, Axelsson T, Agarwal P, Jernberg-Wiklund H, Stamatopoulos K et al: Mantle cell lymphoma displays a homogenous methylation profile: a comparative analysis with chronic lymphocytic leukemia. Am J Hematol 2012, 87(4):361-367.
  6. Ibbotson R, Athanasiadou A, Sutton LA, Davis Z, Gardiner A, Baliakas P, Gunnarsson R, Anagnostopoulos A, Juliusson G, Rosenquist R et al: Coexistence of trisomies of chromosomes 12 and 19 in chronic lymphocytic leukemia occurs exclusively in the rare IgG-positive variant. Leukemia 2012, 26(1):170-172.
  7. Kanduri M, Marincevic M, Halldorsdottir AM, Mansouri L, Junevik K, Ntoufa S, Kultima HG, Isaksson A, Juliusson G, Andersson PO et al: Distinct transcriptional control in major immunogenetic subsets of chronic lymphocytic leukemia exhibiting subset-biased global DNA methylation profiles. Epigenetics 2012, 7(12):1435-1442.
  8. Kostareli E, Gounari M, Agathangelidis A, Stamatopoulos K: Immunoglobulin gene repertoire in chronic lymphocytic leukemia: insight into antigen selection and microenvironmental interactions. Mediterr J Hematol Infect Dis 2012, 4(1):e2012052.
  9. Kostareli E, Gounari M, Janus A, Murray F, Brochet X, Giudicelli V, Pospisilova S, Oscier D, Foroni L, di Celle PF et al: Antigen receptor stereotypy across B-cell lymphoproliferations: the case of IGHV4-59/IGKV3-20 receptors with rheumatoid factor activity. Leukemia 2012, 26(5):1127-1131.
  10. Navarro A, Clot G, Royo C, Jares P, Hadzidimitriou A, Agathangelidis A, Bikos V, Darzentas N, Papadaki T, Salaverria I et al: Molecular subsets of mantle cell lymphoma defined by the IGHV mutational status and SOX11 expression have distinct biologic and clinical features. Cancer Res 2012, 72(20):5307-5316.
  11. Norberg M, Lindhagen E, Kanduri M, Rickardson L, Sundstrom C, Stamatopoulos K, Rosenquist R, Aleskog A: Screening for cytotoxic compounds in poor-prognostic chronic lymphocytic leukemia. Anticancer Res 2012, 32(8):3125-3136.
  12. Ntoufa S, Vardi A, Papakonstantinou N, Anagnostopoulos A, Aleporou-Marinou V, Belessi C, Ghia P, Caligaris-Cappio F, Muzio M, Stamatopoulos K: Distinct innate immunity pathways to activation and tolerance in subgroups of chronic lymphocytic leukemia with distinct immunoglobulin receptors. Mol Med 2012, 18:1281-1291.
  13. Ponzoni M, Kanellis G, Pouliou E, Baliakas P, Scarfo L, Ferreri AJ, Doglioni C, Bikos V, Dagklis A, Anagnostopoulos A et al: Bone marrow histopathology in the diagnostic evaluation of splenic marginal-zone and splenic diffuse red pulp small B-cell lymphoma: a reliable substitute for spleen histopathology? Am J Surg Pathol 2012, 36(11):1609-1618.
  14. Shinawi T, Hill V, Dagklis A, Baliakas P, Stamatopoulos K, Agathanggelou A, Stankovic T, Maher ER, Ghia P, Latif F: KIBRA gene methylation is associated with unfavorable biological prognostic parameters in chronic lymphocytic leukemia. Epigenetics 2012, 7(3):211-215.
  15. Tsakou E, Agathagelidis A, Boudjoghra M, Raff T, Dagklis A, Chatzouli M, Smilevska T, Bourikas G, Merle-Beral H, Manioudaki-Kavallieratou E et al: Partial versus productive immunoglobulin heavy locus rearrangements in chronic lymphocytic leukemia: implications for B-cell receptor stereotypy. Mol Med 2012, 18:138-145.

2011

  1. Agathangelidis A, Hadzidimitriou A, Rosenquist R, Stamatopoulos K: Unlocking the secrets of immunoglobulin receptors in mantle cell lymphoma: implications for the origin and selection of the malignant cells. Semin Cancer Biol 2011, 21(5):299-307.
  2. Arvaniti E, Ntoufa S, Papakonstantinou N, Touloumenidou T, Laoutaris N, Anagnostopoulos A, Lamnissou K, Caligaris-Cappio F, Stamatopoulos K, Ghia P et al: Toll-like receptor signaling pathway in chronic lymphocytic leukemia: distinct gene expression profiles of potential pathogenic significance in specific subsets of patients. Haematologica 2011, 96(11):1644-1652.
  3. Athanasiadou A, Stalika E, Sidi V, Papaioannou M, Gaitatzi M, Anagnostopoulos A: RUNX1-MTG16 fusion gene in de novo acute myeloblastic leukemia with t(16;21)(q24;q22). Leuk Lymphoma 2011, 52(1):145-147.
  4. Berkowska MA, Driessen GJ, Bikos V, Grosserichter-Wagener C, Stamatopoulos K, Cerutti A, He B, Biermann K, Lange JF, van der Burg M et al: Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways. Blood 2011, 118(8):2150-2158.
  5. Hadzidimitriou A, Agathangelidis A, Darzentas N, Murray F, Delfau-Larue MH, Pedersen LB, Lopez AN, Dagklis A, Rombout P, Beldjord K et al: Is there a role for antigen selection in mantle cell lymphoma? Immunogenetic support from a series of 807 cases. Blood 2011, 118(11):3088-3095.
  6. Langerak AW, Davi F, Ghia P, Hadzidimitriou A, Murray F, Potter KN, Rosenquist R, Stamatopoulos K, Belessi C, European Research Initiative on CLL: Immunoglobulin sequence analysis and prognostication in CLL: guidelines from the ERIC review board for reliable interpretation of problematic cases. Leukemia 2011, 25(6):979-984.
  7. Rossi D, Spina V, Deambrogi C, Rasi S, Laurenti L, Stamatopoulos K, Arcaini L, Lucioni M, Rocque GB, Xu-Monette ZY et al: The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation. Blood 2011, 117(12):3391-3401.
  8. Stalika E, Papalexandri A, Kannelis G, Batsis I, Papadaki T, Anagnostopoulos A, Stamatopoulos K: Transient monoclonal CD3+ T large granular lymphocyte proliferation in a case of mantle cell lymphoma with Rituximab-associated late onset neutropenia. Hematol Oncol 2011, 29(3):144-146.
  9. van der Fits L, Sandberg Y, Darzentas N, Zoutman WH, Tielemans D, Wolvers-Tettero IL, Vermeer MH, Langerak AW: A restricted clonal T-cell receptor alphabeta repertoire in Sezary syndrome is indicative of superantigenic stimulation. Br J Dermatol 2011, 165(1):78-84.
  10. Darzentas N, Hadzidimitriou A, Murray F, Hatzi K, Josefsson P, Laoutaris N, Moreno C, Anagnostopoulos A, Jurlander J, Tsaftaris A et al: A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidence. Leukemia 2010, 24(1):125-132.

2010

  1. Forconi F, Potter KN, Wheatley I, Darzentas N, Sozzi E, Stamatopoulos K, Mockridge CI, Packham G, Stevenson FK: The normal IGHV1-69-derived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL. Blood 2010, 115(1):71-77.
  2. Hadzidimitriou A, Darzentas N, Karakoli A, Koliouskas D, Tsaftaris A, Anagnostopoulos A, Stamatopoulos K: Coexistence of different types of biallelic immunoglobulin heavy variable gene replacement events in a case of pediatric B precursor acute lymphoblastic leukemia. Leuk Lymphoma 2010, 51(9):1748-1750.
  3. Kostareli E, Sutton LA, Hadzidimitriou A, Darzentas N, Kouvatsi A, Tsaftaris A, Anagnostopoulos A, Rosenquist R, Stamatopoulos K: Intraclonal diversification of immunoglobulin light chains in a subset of chronic lymphocytic leukemia alludes to antigen-driven clonal evolution. Leukemia 2010, 24(7):1317-1324.
  4. Marantidou F, Dagklis A, Stalika E, Korkolopoulou P, Saetta A, Anagnostopoulos A, Laoutaris N, Stamatopoulos K, Belessi C, Scouras Z et al: Activation-induced cytidine deaminase splicing patterns in chronic lymphocytic leukemia. Blood Cells Mol Dis 2010, 44(4):262-267.
  5. Marincevic M, Cahill N, Gunnarsson R, Isaksson A, Mansouri M, Goransson H, Rasmussen M, Jansson M, Ryan F, Karlsson K et al: High-density screening reveals a different spectrum of genomic aberrations in chronic lymphocytic leukemia patients with ‘stereotyped’ IGHV3-21 and IGHV4-34 B-cell receptors. Haematologica 2010, 95(9):1519-1525.
  6. Marincevic M, Mansouri M, Kanduri M, Isaksson A, Goransson H, Smedby KE, Jurlander J, Juliusson G, Davi F, Stamatopoulos K et al: Distinct gene expression profiles in subsets of chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors. Haematologica 2010, 95(12):2072-2079.
  7. Salido M, Baro C, Oscier D, Stamatopoulos K, Dierlamm J, Matutes E, Traverse-Glehen A, Berger F, Felman P, Thieblemont C et al: Cytogenetic aberrations and their prognostic value in a series of 330 splenic marginal zone B-cell lymphomas: a multicenter study of the Splenic B-Cell Lymphoma Group. Blood 2010, 116(9):1479-1488.
  8. Spanoudakis M, Koutala H, Ximeri M, Pyrovolaki K, Stamatopoulos K, Papadaki HA: T-cell receptor Vbeta repertoire analysis in patients with chronic idiopathic neutropenia demonstrates the presence of aberrant T-cell expansions. Clin Immunol 2010, 137(3):384-395.
  9. Stamatopoulos K: Antigens in CLL: themes and variations. Blood 2010, 115(19):3855-3856.

2009

  1. Dagklis A, Fazi C, Sala C, Cantarelli V, Scielzo C, Massacane R, Toniolo D, Caligaris-Cappio F, Stamatopoulos K, Ghia P: The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)-like monoclonal B lymphocytosis is different from CLL: diagnostic implications for clinical monitoring. Blood 2009, 114(1):26-32.
  2. Hadzidimitriou A, Darzentas N, Murray F, Smilevska T, Arvaniti E, Tresoldi C, Tsaftaris A, Laoutaris N, Anagnostopoulos A, Davi F et al: Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia. Blood 2009, 113(2):403-411.
  3. Kostareli E, Hadzidimitriou A, Stavroyianni N, Darzentas N, Athanasiadou A, Gounari M, Bikos V, Agathagelidis A, Touloumenidou T, Zorbas I et al: Molecular evidence for EBV and CMV persistence in a subset of patients with chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors. Leukemia 2009, 23(5):919-924.
  4. Stamatopoulos K: CLL: promiscuity leads to risks. Blood 2009, 114(17):3508-3509.
  5. Sutton LA, Kostareli E, Hadzidimitriou A, Darzentas N, Tsaftaris A, Anagnostopoulos A, Rosenquist R, Stamatopoulos K: Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: implications for ongoing interactions with antigen. Blood 2009, 114(20):4460-4468.

2008

  1. Athanasiadou A, Stamatopoulos K, Gaitatzi M, Stavroyianni N, Fassas A, Anagnostopoulos A: Recurrent cytogenetic findings in subsets of patients with chronic lymphocytic leukemia expressing IgG-switched stereotyped immunoglobulins. Haematologica 2008, 93(3):473-474.
  2. Chiotoglou I, Smilevska T, Samara M, Likousi S, Belessi C, Athanasiadou I, Stavroyianni N, Samara S, Laoutaris N, Vamvakopoulos N et al: Predominantly post-transcriptional regulation of activation molecules in chronic lymphocytic leukemia: the case of transferrin receptors. Blood Cells Mol Dis 2008, 41(2):203-209.
  3. Davi F, Rosenquist R, Ghia P, Belessi C, Stamatopoulos K: Determination of IGHV gene mutational status in chronic lymphocytic leukemia: bioinformatics advances meet clinical needs. Leukemia 2008, 22(1):212-214.
  4. Ghia P, Chiorazzi N, Stamatopoulos K: Microenvironmental influences in chronic lymphocytic leukaemia: the role of antigen stimulation. J Intern Med 2008, 264(6):549-562.
  5. Kostareli E, Smilevska T, Stamatopoulos K, Kouvatsi A, Anagnostopoulos A: Chronic lymphocytic leukaemia: an immunobiology approach. Srp Arh Celok Lek 2008, 136(5-6):319-323.
  6. Matutes E, Oscier D, Montalban C, Berger F, Callet-Bauchu E, Dogan A, Felman P, Franco V, Iannitto E, Mollejo M et al: Splenic marginal zone lymphoma proposals for a revision of diagnostic, staging and therapeutic criteria. Leukemia 2008, 22(3):487-495.
  7. Murray F, Darzentas N, Hadzidimitriou A, Tobin G, Boudjogra M, Scielzo C, Laoutaris N, Karlsson K, Baran-Marzsak F, Tsaftaris A et al: Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis. Blood 2008, 111(3):1524-1533.
  8. Papadaki T, Stamatopoulos K, Mavrommatis T, Anagnostopoulos A, Anagnostou D: A unique case of IgD-only splenic marginal-zone lymphoma with mutated immunoglobulin genes: ontogenetic implications. Leuk Res 2008, 32(1):155-157.
  9. Smilevska T, Tsakou E, Hadzidimitriou A, Bikos V, Stavroyianni N, Laoutaris N, Fassas A, Alphanagnostopoulos A, Papadaki T, Belessi C et al: Immunoglobulin kappa gene repertoire and somatic hypermutation patterns in follicular lymphoma. Blood Cells Mol Dis 2008, 41(2):215-218.
  10. Stamatopoulos K, Papadaki T, Pontikoglou C, Athanasiadou I, Stavroyianni N, Bux J, Batsis I, Pyrovolaki K, Paterakis G, Anagnostou D et al: Lymphocyte subpopulation imbalances, bone marrow hematopoiesis and histopathology in rituximab-treated lymphoma patients with late-onset neutropenia. Leukemia 2008, 22(7):1446-1449.