Informatics for Big Bio-Data – Publications


  1. Chouvarda I, Maglaveras N: Medical Informatics Education & Research in Greece. Yearbook of medical informatics 2015, 10(1):220-226.
  2. Chouvarda IG, Babalis D, Papaioannou V, Maglaveras N, Georgopoulos D: Multiparametric modeling of the ineffective efforts in assisted ventilation within an ICU. Medical & biological engineering & computing 2015.
  3. Chouvarda IG, Goulis DG, Lambrinoudaki I, Maglaveras N: Connected health and integrated care: Toward new models for chronic disease management. Maturitas 2015, 82(1):22-27.
  4. Dakos G, Konstantinou D, Chatzizisis YS, Chouvarda I, Filos D, Paraskevaidis S, Mantziari L, Maglaveras N, Karvounis H, Vassilikos V: P wave analysis with wavelets identifies hypertensive patients at risk of recurrence of atrial fibrillation: A case-control study and 1year follow-up. Journal of electrocardiology 2015, 48(5):845-852.
  5. Toutouzas K, Chatzizisis YS, Riga M, Giannopoulos A, Antoniadis AP, Tu S, Fujino Y, Mitsouras D, Doulaverakis C, Tsampoulatidis I et al: Accurate and reproducible reconstruction of coronary arteries and endothelial shear stress calculation using 3D OCT: comparative study to 3D IVUS and 3D QCA. Atherosclerosis 2015, 240(2):510-519.


  1. Koutkias V, Kaklanis N, Votis K, Tzovaras D, Maglaveras N: An integrated semantic framework supporting universal accessibility to ICT. Univ Access Inf Soc 2014, 4(2):1-14.
  2. Malousi A, Papakonstantinou N, Tsagiopoulou M, Stamatopoulos K, Maglaveras N: Computational Analysis of Pathways Enrichment in DNA Methylation Array Data. In: The International Conference on Health Informatics. Edited by Zhang Y-T, vol. 42: Springer International Publishing; 2014: 144-147.
  3. Zarpalas D, Gkontra P, Daras P, Maglaveras N: Gradient-Based Reliability Maps for ACM-Based Segmentation of Hippocampus. Biomedical Engineering, IEEE Transactions on 2014, 61(4):1015-1026.
  4. Zarpalas D, Gkontra P, Daras P, Maglaveras N: Accurate and Fully Automatic Hippocampus Segmentation Using Subject-Specific 3D Optimal Local Maps Into a Hybrid Active Contour Model. Translational Engineering in Health and Medicine, IEEE Journal of 2014, 2:1-16.


  1. Kilintzis V, Moulos I, Koutkias V, Maglaveras N: Exploiting the universAAL platform for the design and development of a physical activity monitoring application. In: Proceedings of the 6th International Conference on PErvasive Technologies Related to Assistive Environments. Rhodes, Greece: ACM; 2013: 1-4.
  2. Vassilis Koutkias, Evangelos Bekiaris, Nicos Maglaveras, Maria Gkemou: Towards an ontology-based model for user profile representation in a cloud infrastructure. International Journal of Electronic Commerce Studies 2013, 4(5):349-354.


  1. Chouvarda I, Mendez MO, Rosso V, Bianchi AM, Parrino L, Grassi A, Terzano MG, Cerutti S, Maglaveras N: Cyclic alternating patterns in normal sleep and insomnia: structure and content differences. IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society 2012, 20(5):642-652.
  2. Fountoulakis K, Lekka E, Kouidi E, Chouvarda I, Deligiannis A, Maglaveras N: Development of the Global Disability Scale (Glo.Di.S): preliminary results. Annals of General Psychiatry 2012, 11(1):14.
  3. Kokkinaki A, Chouvarda I, Maglaveras N: Searching biosignal databases by content and context: Research Oriented Integration System for ECG Signals (ROISES). Computer methods and programs in biomedicine 2012, 108(2):453-466.
  4. Koutkias V, Kilintzis V, Stalidis G, Lazou K, Nies J, Durand-Texte L, McNair P, Beuscart R, Maglaveras N: Knowledge engineering for adverse drug event prevention: on the design and development of a uniform, contextualized and sustainable knowledge-based framework. Journal of biomedical informatics 2012, 45(3):495-506.
  5. Papaioannou VE, Chouvarda IG, Maglaveras NK, Pneumatikos IA: Temperature variability analysis using wavelets and multiscale entropy in patients with systemic inflammatory response syndrome, sepsis, and septic shock. Critical care (London, England) 2012, 16(2):R51.
  6. Triantafyllidis A, Koutkias V, Moulos I, Maglaveras N: On Location-Based Services for Patient Empowerment, Guidance and Safety. In: Wireless Mobile Communication and Healthcare. Edited by Nikita K, Lin J, Fotiadis D, Arredondo Waldmeyer M-T, vol. 83: Springer Berlin Heidelberg; 2012: 416-422.


  1. Anastasiadou C, Malousi A, Maglaveras N, Kouidou S: Human epigenome data reveal increased CpG methylation in alternatively spliced sites and putative exonic splicing enhancers. DNA and cell biology 2011, 30(5):267-275.
  2. Bekiaris A, Mourouzis A, Maglaveras N: The REMOTE AAL Project: Remote Health and Social Care for Independent Living of Isolated Elderly with Chronic Conditions. In: Universal Access in Human-Computer Interaction Context Diversity. Edited by Stephanidis C, vol. 6767: Springer Berlin Heidelberg; 2011: 131-140.
  3. Chouvarda I, Mendez MO, Rosso V, Bianchi AM, Parrino L, Grassi A, Terzano M, Maglaveras N, Cerutti S: Predicting EEG complexity from sleep macro and microstructure. Physiological measurement 2011, 32(8):1083-1101.
  4. Kilintzis V, Pappas T, Chouvarda I, Salonikiou A, Maglaveras N, Dimitrakos S, Topouzis F: Novel Heidelberg retina tomograph-based morphological parameters derived from optic disc cupping surface processing. Investigative ophthalmology & visual science 2011, 52(2):947-951.
  5. Mourouzis A, Leonidis A, Foukarakis M, Antona M, Maglaveras N: A Novel Design Approach for Multi-device Adaptable User Interfaces: Concepts, Methods and Examples. In: Universal Access in Human-Computer Interaction Design for All and eInclusion. Edited by Stephanidis C, vol. 6765: Springer Berlin Heidelberg; 2011: 400-409.
  6. Papaioannou V, Chouvarda I, Maglaveras N, Pneumatikos I: Study of multiparameter respiratory pattern complexity in surgical critically ill patients during weaning trials. BMC Physiol 2011, 11(1):1-15.
  7. Papaioannou VE, Chouvarda I, Maglaveras N, Dragoumanis C, Pneumatikos I: Changes of heart and respiratory rate dynamics during weaning from mechanical ventilation: a study of physiologic complexity in surgical critically ill patients. J Crit Care 2011, 26(3):262-272.


  1. Karambataki M, Malousi A, Maglaveras N, Kouidou S: Synonymous polymorphisms at splicing regulatory sites are associated with CpGs in neurodegenerative disease-related genes. Neuromolecular medicine 2010, 12(3):260-269.
  2. Koutkias VG, Chouvarda I, Triantafyllidis A, Malousi A, Giaglis GD, Maglaveras N: A Personalized Framework for Medication Treatment Management in Chronic Care. Information Technology in Biomedicine, IEEE Transactions on 2010, 14(2):464-472.
  3. Maglaveras N, Bonato P, Tamura T: Guest Editorial Special Section on Personal Health Systems. Information Technology in Biomedicine, IEEE Transactions on 2010, 14(2):360-363.
  4. Malousi A, Chouvarda I, Koutkias V, Kouidou S, Maglaveras N: SpliceIT: a hybrid method for splice signal identification based on probabilistic and biological inference. Journal of biomedical informatics 2010, 43(2):208-217.
  5. Vassilikos VP, Vogas V, Giannakoulas G, Mantziari L, Lekka I, Dimitrakopoulos K, Paraskevaidis S, Konias S, Maglavelas N, Chouvarda I et al: The use of transtelephonic loop recorders for the assessment of symptoms and arrhythmia recurrence after radiofrequency catheter ablation. Telemedicine journal and e-health : the official journal of the American Telemedicine Association 2010, 16(7):792-798.


  1. Agorastos T, Koutkias V, Falelakis M, Lekka I, Mikos T, Delopoulos A, Mitkas PA, Tantsis A, Weyers S, Coorevits P et al: Semantic Integration of Cervical Cancer Data Repositories to Facilitate Multicenter Association Studies: The ASSIST Approach. Cancer Informatics 2009, 8:31-44.
  2. Kouidou S, Malousi A, Maglaveras N: Li–Fraumeni and Li–Fraumeni-like syndrome mutations in p53 are associated with exonic methylation and splicing regulatory elements. Molecular Carcinogenesis 2009, 48(10):895-902.


  1. Malousi A, Maglaveras N, Kouidou S: Intronic CpG content and alternative splicing in human genes containing a single cassette exon. Epigenetics : official journal of the DNA Methylation Society 2008, 3(2):69-73.
  2. Papaioannou V, Giannakou M, Maglaveras N, Sofianos E, Giala M: Investigation of heart rate and blood pressure variability, baroreflex sensitivity, and approximate entropy in acute brain injury patients. J Crit Care 2008, 23(3):380-386.
  3. Spyrou S, Bamidis PD, Maglaveras N, Pangalos G, Pappas C: A Methodology for Reliability Analysis in Health Networks. Information Technology in Biomedicine, IEEE Transactions on 2008, 12(3):377-386.
  4. Triantafyllidis A, Koutkias V, Chouvarda I, Maglaveras N: An open and reconfigurable wireless sensor network for pervasive health monitoring. Methods of information in medicine 2008, 47(3):229-234.


  1. Bratsas C, Koutkias V, Kaimakamis E, Bamidis PD, Pangalos GI, Maglaveras N: KnowBaSICS-M: an ontology-based system for semantic management of medical problems and computerised algorithmic solutions. Computer methods and programs in biomedicine 2007, 88(1):39-51.
  2. Giannoglou GD, Chatzizisis YS, Koutkias V, Kompatsiaris I, Papadogiorgaki M, Mezaris V, Parissi E, Diamantopoulos P, Strintzis MG, Maglaveras N et al: A novel active contour model for fully automated segmentation of intravascular ultrasound images: in vivo validation in human coronary arteries. Computers in biology and medicine 2007, 37(9):1292-1302.
  3. Kouidou S, Malousi A, Kyventidis A, Fragou A, Maglaveras N: G:C > A:T mutations and potential epigenetic regulation of p53 in breast cancer. Breast cancer research and treatment 2007, 106(3):351-360.
  4. Koutkias VG, Malousi A, Maglaveras N: Engineering agent-mediated integration of bioinformatics analysis tools. Multiagent Grid Syst 2007, 3(2):245-258.
  5. Papadelis C, Chen Z, Kourtidou-Papadeli C, Bamidis PD, Chouvarda I, Bekiaris E, Maglaveras N: Monitoring sleepiness with on-board electrophysiological recordings for preventing sleep-deprived traffic accidents. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2007, 118(9):1906-1922.
  6. Papadelis C, Kourtidou-Papadeli C, Bamidis PD, Maglaveras N, Pappas K: The effect of hypobaric hypoxia on multichannel EEG signal complexity. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2007, 118(1):31-52.
  7. Siebes M, Viceconti M, Maglaveras N, Kirkpatrick CJ: Engineering for Health – A Partner in Building the Knowledge Economy of Europe. Engineering in Medicine and Biology Magazine, IEEE 2007, 26(3):53-59.


  1. Giannoglou GD, Chatzizisis YS, Sianos G, Tsikaderis D, Matakos A, Koutkias V, Diamantopoulos P, Maglaveras N, Parcharidis GE, Louridas GE: Integration of multi-modality imaging for accurate 3D reconstruction of human coronary arteries in vivo. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 2006, 569(2):310-313.
  2. Giannoglou GD, Chatzizisis YS, Sianos G, Tsikaderis D, Matakos A, Koutkias V, Diamantopoulos P, Maglaveras N, Parcharidis GE, Louridas GE: In-vivo validation of spatially correct three-dimensional reconstruction of human coronary arteries by integrating intravascular ultrasound and biplane angiography. Coronary artery disease 2006, 17(6):533-543.
  3. Kouidou S, Malousi A, Maglaveras N: Methylation and repeats in silent and nonsense mutations of p53. Mutation research 2006, 599(1-2):167-177.
  4. Papadelis C, Maglaveras N, Kourtidou-Papadeli C, Bamidis P, Albani M, Chatzinikolaou K, Pappas K: Quantitative multichannel EEG measure predicting the optimal weaning from ventilator in ICU patients with acute respiratory failure. Clinical Neurophysiology 2006, 117(4):752-770.
  5. Papaioannou VE, Maglaveras N, Houvarda I, Antoniadou E, Vretzakis G: Investigation of altered heart rate variability, nonlinear properties of heart rate signals, and organ dysfunction longitudinally over time in intensive care unit patients. J Crit Care 2006, 21(1):95-103; discussion 103-104.