Informatics for Big Bio-Data – Publications


  1. Knowledge Base workgroup of the Observational Health Data Sciences and Informatics (OHDSI) collaborative. Large-scale adverse effects related to treatment evidence standardization (LAERTES): an open scalable system for linking pharmacovigilance evidence sources with clinical data. J Biomed Semantics. 2017 Mar 7;8(1):11. doi: 10.1186/s13326-017-0115-3. PubMed PMID: 28270198; PubMed Central PMCID: PMC5341176.
  2. Caron A, Chazard E, Muller J, Perichon R, Ferret L, Koutkias V, Beuscart R, Beuscart JB, Ficheur G. IT-CARES: an interactive tool for case-crossover analyses of electronic medical records for patient safety. J Am Med Inform Assoc. 2017 Mar 1;24(2):323-330. doi: 10.1093/jamia/ocw132. PubMed PMID: 27678461; PubMed Central PMCID: PMC5391728.
  3. Vaporidi K, Babalis D, Chytas A, Lilitsis E, Kondili E, Amargianitakis V, Chouvarda I, Maglaveras N, Georgopoulos D. Clusters of ineffective efforts during mechanical ventilation: impact on outcome. Intensive Care Med. 2017 Feb;43(2):184-191. doi: 10.1007/s00134-016-4593-z. Epub 2016 Oct 24. PubMed PMID: 27778044.
  4. Kavakiotis I, Tsave O, Salifoglou A, Maglaveras N, Vlahavas I, Chouvarda I. Machine Learning and Data Mining Methods in Diabetes Research. Comput Struct Biotechnol J. 2017 Jan 8;15:104-116. doi: 10.1016/j.csbj.2016.12.005. eCollection 2017. Review. PubMed PMID: 28138367; PubMed Central PMCID: PMC5257026.
  5. Claes J, Buys R, Woods C, Briggs A, Geue C, Aitken M, Moyna N, Moran K, McCaffrey N, Chouvarda I, Walsh D, Budts W, Filos D, Triantafyllidis A, Maglaveras N, Cornelissen VA. PATHway I: design and rationale for the investigation of the feasibility, clinical effectiveness and cost-effectiveness of a technology-enabled cardiac rehabilitation platform. BMJ Open. 2017 Jun 30;7(6):e016781. doi: 10.1136/bmjopen-2017-016781. PubMed PMID: 28667228.


  1. Chatzizisis YS, Toutouzas K, Giannopoulos AA, Riga M, Antoniadis AP, Fujinom Y, Mitsouras D, Koutkias VG, Cheimariotis G, Doulaverakis C, Tsampoulatidis I, Chouvarda I, Kompatsiaris I, Nakamura S, Rybicki FJ, Maglaveras N, Tousoulis D, Giannoglou GD. Association of global and local low endothelial shear stress with high-risk plaque using intracoronary 3D optical coherence tomography: Introduction of ‘shear stress score’. Eur Heart J Cardiovasc Imaging. 2016 Jul 26. pii: jew134. [Epub ahead of print] PubMed PMID: 27461211.
  2. Koutkias V, Bouaud J. Computerized Clinical Decision Support: Contributions from 2015. Yearb Med Inform. 2016 Nov 10;(1):170-177. PubMed PMID: 27830247.
  3. Koutkias VG, Lillo-Le Louët A, Jaulent MC. Exploiting heterogeneous publicly available data sources for drug safety surveillance: computational framework and case studies. Expert Opin Drug Saf. 2017 Feb;16(2):113-124. doi: 10.1080/14740338.2017.1257604. Epub 2016 Dec 1. PubMed PMID: 27813420.
  4. Triantafyllidis AK, Koutkias VG, Chouvarda I, Adami I, Kouroubali A, Maglaveras N. Framework of sensor-based monitoring for pervasive patient care. Healthc Technol Lett. 2016 Aug 12;3(3):153-158. eCollection 2016 Sep. PubMed PMID: 27733920; PubMed Central PMCID: PMC5047273.


  1. Chouvarda I, Maglaveras N: Medical Informatics Education & Research in Greece. Yearbook of medical informatics 2015, 10(1):220-226.
  2. Chouvarda IG, Babalis D, Papaioannou V, Maglaveras N, Georgopoulos D: Multiparametric modeling of the ineffective efforts in assisted ventilation within an ICU. Medical & biological engineering & computing 2015.
  3. Chouvarda IG, Goulis DG, Lambrinoudaki I, Maglaveras N: Connected health and integrated care: Toward new models for chronic disease management. Maturitas 2015, 82(1):22-27.
  4. Dakos G, Konstantinou D, Chatzizisis YS, Chouvarda I, Filos D, Paraskevaidis S, Mantziari L, Maglaveras N, Karvounis H, Vassilikos V: P wave analysis with wavelets identifies hypertensive patients at risk of recurrence of atrial fibrillation: A case-control study and 1year follow-up. Journal of electrocardiology 2015, 48(5):845-852.
  5. Toutouzas K, Chatzizisis YS, Riga M, Giannopoulos A, Antoniadis AP, Tu S, Fujino Y, Mitsouras D, Doulaverakis C, Tsampoulatidis I et al: Accurate and reproducible reconstruction of coronary arteries and endothelial shear stress calculation using 3D OCT: comparative study to 3D IVUS and 3D QCA. Atherosclerosis 2015, 240(2):510-519.


  1. Koutkias V, Kaklanis N, Votis K, Tzovaras D, Maglaveras N: An integrated semantic framework supporting universal accessibility to ICT. Univ Access Inf Soc 2014, 4(2):1-14.
  2. Malousi A, Papakonstantinou N, Tsagiopoulou M, Stamatopoulos K, Maglaveras N: Computational Analysis of Pathways Enrichment in DNA Methylation Array Data. In: The International Conference on Health Informatics. Edited by Zhang Y-T, vol. 42: Springer International Publishing; 2014: 144-147.
  3. Zarpalas D, Gkontra P, Daras P, Maglaveras N: Gradient-Based Reliability Maps for ACM-Based Segmentation of Hippocampus. Biomedical Engineering, IEEE Transactions on 2014, 61(4):1015-1026.
  4. Zarpalas D, Gkontra P, Daras P, Maglaveras N: Accurate and Fully Automatic Hippocampus Segmentation Using Subject-Specific 3D Optimal Local Maps Into a Hybrid Active Contour Model. Translational Engineering in Health and Medicine, IEEE Journal of 2014, 2:1-16.


  1. Kilintzis V, Moulos I, Koutkias V, Maglaveras N: Exploiting the universAAL platform for the design and development of a physical activity monitoring application. In: Proceedings of the 6th International Conference on PErvasive Technologies Related to Assistive Environments. Rhodes, Greece: ACM; 2013: 1-4.
  2. Vassilis Koutkias, Evangelos Bekiaris, Nicos Maglaveras, Maria Gkemou: Towards an ontology-based model for user profile representation in a cloud infrastructure. International Journal of Electronic Commerce Studies 2013, 4(5):349-354.


  1. Chouvarda I, Mendez MO, Rosso V, Bianchi AM, Parrino L, Grassi A, Terzano MG, Cerutti S, Maglaveras N: Cyclic alternating patterns in normal sleep and insomnia: structure and content differences. IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society 2012, 20(5):642-652.
  2. Fountoulakis K, Lekka E, Kouidi E, Chouvarda I, Deligiannis A, Maglaveras N: Development of the Global Disability Scale (Glo.Di.S): preliminary results. Annals of General Psychiatry 2012, 11(1):14.
  3. Kokkinaki A, Chouvarda I, Maglaveras N: Searching biosignal databases by content and context: Research Oriented Integration System for ECG Signals (ROISES). Computer methods and programs in biomedicine 2012, 108(2):453-466.
  4. Koutkias V, Kilintzis V, Stalidis G, Lazou K, Nies J, Durand-Texte L, McNair P, Beuscart R, Maglaveras N: Knowledge engineering for adverse drug event prevention: on the design and development of a uniform, contextualized and sustainable knowledge-based framework. Journal of biomedical informatics 2012, 45(3):495-506.
  5. Papaioannou VE, Chouvarda IG, Maglaveras NK, Pneumatikos IA: Temperature variability analysis using wavelets and multiscale entropy in patients with systemic inflammatory response syndrome, sepsis, and septic shock. Critical care (London, England) 2012, 16(2):R51.
  6. Triantafyllidis A, Koutkias V, Moulos I, Maglaveras N: On Location-Based Services for Patient Empowerment, Guidance and Safety. In: Wireless Mobile Communication and Healthcare. Edited by Nikita K, Lin J, Fotiadis D, Arredondo Waldmeyer M-T, vol. 83: Springer Berlin Heidelberg; 2012: 416-422.


  1. Anastasiadou C, Malousi A, Maglaveras N, Kouidou S: Human epigenome data reveal increased CpG methylation in alternatively spliced sites and putative exonic splicing enhancers. DNA and cell biology 2011, 30(5):267-275.
  2. Bekiaris A, Mourouzis A, Maglaveras N: The REMOTE AAL Project: Remote Health and Social Care for Independent Living of Isolated Elderly with Chronic Conditions. In: Universal Access in Human-Computer Interaction Context Diversity. Edited by Stephanidis C, vol. 6767: Springer Berlin Heidelberg; 2011: 131-140.
  3. Chouvarda I, Mendez MO, Rosso V, Bianchi AM, Parrino L, Grassi A, Terzano M, Maglaveras N, Cerutti S: Predicting EEG complexity from sleep macro and microstructure. Physiological measurement 2011, 32(8):1083-1101.
  4. Kilintzis V, Pappas T, Chouvarda I, Salonikiou A, Maglaveras N, Dimitrakos S, Topouzis F: Novel Heidelberg retina tomograph-based morphological parameters derived from optic disc cupping surface processing. Investigative ophthalmology & visual science 2011, 52(2):947-951.
  5. Mourouzis A, Leonidis A, Foukarakis M, Antona M, Maglaveras N: A Novel Design Approach for Multi-device Adaptable User Interfaces: Concepts, Methods and Examples. In: Universal Access in Human-Computer Interaction Design for All and eInclusion. Edited by Stephanidis C, vol. 6765: Springer Berlin Heidelberg; 2011: 400-409.
  6. Papaioannou V, Chouvarda I, Maglaveras N, Pneumatikos I: Study of multiparameter respiratory pattern complexity in surgical critically ill patients during weaning trials. BMC Physiol 2011, 11(1):1-15.
  7. Papaioannou VE, Chouvarda I, Maglaveras N, Dragoumanis C, Pneumatikos I: Changes of heart and respiratory rate dynamics during weaning from mechanical ventilation: a study of physiologic complexity in surgical critically ill patients. J Crit Care 2011, 26(3):262-272.


  1. Karambataki M, Malousi A, Maglaveras N, Kouidou S: Synonymous polymorphisms at splicing regulatory sites are associated with CpGs in neurodegenerative disease-related genes. Neuromolecular medicine 2010, 12(3):260-269.
  2. Koutkias VG, Chouvarda I, Triantafyllidis A, Malousi A, Giaglis GD, Maglaveras N: A Personalized Framework for Medication Treatment Management in Chronic Care. Information Technology in Biomedicine, IEEE Transactions on 2010, 14(2):464-472.
  3. Maglaveras N, Bonato P, Tamura T: Guest Editorial Special Section on Personal Health Systems. Information Technology in Biomedicine, IEEE Transactions on 2010, 14(2):360-363.
  4. Malousi A, Chouvarda I, Koutkias V, Kouidou S, Maglaveras N: SpliceIT: a hybrid method for splice signal identification based on probabilistic and biological inference. Journal of biomedical informatics 2010, 43(2):208-217.
  5. Vassilikos VP, Vogas V, Giannakoulas G, Mantziari L, Lekka I, Dimitrakopoulos K, Paraskevaidis S, Konias S, Maglavelas N, Chouvarda I et al: The use of transtelephonic loop recorders for the assessment of symptoms and arrhythmia recurrence after radiofrequency catheter ablation. Telemedicine journal and e-health : the official journal of the American Telemedicine Association 2010, 16(7):792-798.


  1. Agorastos T, Koutkias V, Falelakis M, Lekka I, Mikos T, Delopoulos A, Mitkas PA, Tantsis A, Weyers S, Coorevits P et al: Semantic Integration of Cervical Cancer Data Repositories to Facilitate Multicenter Association Studies: The ASSIST Approach. Cancer Informatics 2009, 8:31-44.
  2. Kouidou S, Malousi A, Maglaveras N: Li–Fraumeni and Li–Fraumeni-like syndrome mutations in p53 are associated with exonic methylation and splicing regulatory elements. Molecular Carcinogenesis 2009, 48(10):895-902.


  1. Malousi A, Maglaveras N, Kouidou S: Intronic CpG content and alternative splicing in human genes containing a single cassette exon. Epigenetics : official journal of the DNA Methylation Society 2008, 3(2):69-73.
  2. Papaioannou V, Giannakou M, Maglaveras N, Sofianos E, Giala M: Investigation of heart rate and blood pressure variability, baroreflex sensitivity, and approximate entropy in acute brain injury patients. J Crit Care 2008, 23(3):380-386.
  3. Spyrou S, Bamidis PD, Maglaveras N, Pangalos G, Pappas C: A Methodology for Reliability Analysis in Health Networks. Information Technology in Biomedicine, IEEE Transactions on 2008, 12(3):377-386.
  4. Triantafyllidis A, Koutkias V, Chouvarda I, Maglaveras N: An open and reconfigurable wireless sensor network for pervasive health monitoring. Methods of information in medicine 2008, 47(3):229-234.


  1. Bratsas C, Koutkias V, Kaimakamis E, Bamidis PD, Pangalos GI, Maglaveras N: KnowBaSICS-M: an ontology-based system for semantic management of medical problems and computerised algorithmic solutions. Computer methods and programs in biomedicine 2007, 88(1):39-51.
  2. Giannoglou GD, Chatzizisis YS, Koutkias V, Kompatsiaris I, Papadogiorgaki M, Mezaris V, Parissi E, Diamantopoulos P, Strintzis MG, Maglaveras N et al: A novel active contour model for fully automated segmentation of intravascular ultrasound images: in vivo validation in human coronary arteries. Computers in biology and medicine 2007, 37(9):1292-1302.
  3. Kouidou S, Malousi A, Kyventidis A, Fragou A, Maglaveras N: G:C > A:T mutations and potential epigenetic regulation of p53 in breast cancer. Breast cancer research and treatment 2007, 106(3):351-360.
  4. Koutkias VG, Malousi A, Maglaveras N: Engineering agent-mediated integration of bioinformatics analysis tools. Multiagent Grid Syst 2007, 3(2):245-258.
  5. Papadelis C, Chen Z, Kourtidou-Papadeli C, Bamidis PD, Chouvarda I, Bekiaris E, Maglaveras N: Monitoring sleepiness with on-board electrophysiological recordings for preventing sleep-deprived traffic accidents. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2007, 118(9):1906-1922.
  6. Papadelis C, Kourtidou-Papadeli C, Bamidis PD, Maglaveras N, Pappas K: The effect of hypobaric hypoxia on multichannel EEG signal complexity. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2007, 118(1):31-52.
  7. Siebes M, Viceconti M, Maglaveras N, Kirkpatrick CJ: Engineering for Health – A Partner in Building the Knowledge Economy of Europe. Engineering in Medicine and Biology Magazine, IEEE 2007, 26(3):53-59.


  1. Giannoglou GD, Chatzizisis YS, Sianos G, Tsikaderis D, Matakos A, Koutkias V, Diamantopoulos P, Maglaveras N, Parcharidis GE, Louridas GE: Integration of multi-modality imaging for accurate 3D reconstruction of human coronary arteries in vivo. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 2006, 569(2):310-313.
  2. Giannoglou GD, Chatzizisis YS, Sianos G, Tsikaderis D, Matakos A, Koutkias V, Diamantopoulos P, Maglaveras N, Parcharidis GE, Louridas GE: In-vivo validation of spatially correct three-dimensional reconstruction of human coronary arteries by integrating intravascular ultrasound and biplane angiography. Coronary artery disease 2006, 17(6):533-543.
  3. Kouidou S, Malousi A, Maglaveras N: Methylation and repeats in silent and nonsense mutations of p53. Mutation research 2006, 599(1-2):167-177.
  4. Papadelis C, Maglaveras N, Kourtidou-Papadeli C, Bamidis P, Albani M, Chatzinikolaou K, Pappas K: Quantitative multichannel EEG measure predicting the optimal weaning from ventilator in ICU patients with acute respiratory failure. Clinical Neurophysiology 2006, 117(4):752-770.
  5. Papaioannou VE, Maglaveras N, Houvarda I, Antoniadou E, Vretzakis G: Investigation of altered heart rate variability, nonlinear properties of heart rate signals, and organ dysfunction longitudinally over time in intensive care unit patients. J Crit Care 2006, 21(1):95-103; discussion 103-104.