Health Translational Research


Health Translational Research at INAB revolves around the development and validation of innovative methodologies, products and services of medical interest in order to facilitate the transition “from bench to bedside” in line with the concept of personalized medicine and rational management of patients while minimizing unnecessary costs and toxicities.

Immunogenetic analysis for unique scenarios of clinical value in immunology
- Architecture of immune repertoires
- Characteristics of Somatic Hypermutation Mechanism (SHM)
- Clonal dynamics of immune repertoires with special focus on minimal residual disease (MRD)
- Sequence / structure / function relationships bridging the gap from genes to immune receptor specificities

- Immune signaling in Chronic Lymphocytic Leukemia

Lymphocytes and microenvironment
- Identification of new biomarkers and novel therapeutic targets
- Analysis of treatment resistance

Epigenetics (DNA Methylation and microRNA studies)
Carcinogenesis is a multistep process, including initiation, promotion and progression, and a multifactorial pathology characterized by the accumulation of a multitude of alterations including genetic, cytogenetic, and epigenetic changes. A crucial and complementary player in gene regulation, epigenetics, has come to be associated with cancer initiation and development. Epigenetics may be defined as the mechanisms that initiate and maintain heritable patterns of gene function and regulation without affecting the sequence of the genome.
- The histone methyltransferase EZH2 as a novel therapeutic target in Chronic Lymphocytic Leukemia
- Differential DNA methylation patterns leading to differential gene expression: identifying p63 as a novel player in CLL

Flow Cytometry
- Automated Flow Cytometry analysis

Registration and Management systems for clinicobiological data
- CMLab-GR
- CLL-Registry
Novel gene and cell therapy approaches for difficult to cure hematological diseases, both congenital and acquired
- Large scale generation and validation of Aspegillus–specific T cells

Pharmacological studies
- Quality assessment of biosimilar medicines
- Bioprospecting activities related to novel compounds identified/designed also through the activities of the Agri-biotechnology sector

Different objectives and types of data require different statistical techniques. INAB currently runs three large research projects on processes related to bio medical data where statistics plays a substantial supportive and progressive role. These projects are based on different types of data, in particular, large-scale biological data (1), clinical data (2), but also text data that provide additional, ontology-based information, which is incorporated and utilized (3).
Genome wide DNA Methylation studies in lymphoid malignancies
Cervical Cancer screening strategies
Validating Semantic Similarity in biological data

Future trends for e-infrastructures and life sciences