Complete genotypic and phenotypic analysis of acquired diseases of the hemopoietic tissue: pathogenetic, diagnostic and therapeutic extensions
Funding Body: General Secretariat for Research and Technology of Greece
SYNERGASIA – ACTION 1 – National Strategic Reference Framework 2007 – 2013
January 2012 – January 2015
The present proposal concerns the support and conduct of an interdisciplinary research on the analysis of “representative” disorders for major disease entities in the field of Hematology.
Chronic Lymphocytic Leukemia (an archetyic lymphoprolipherative disorder) and Chronic Idiopathic Neutropenia (an exemplary of bone marrow deficiencies) are disorders with unclear underlying pathogenic mechanisms and great heterogeneity in terms of clinical presentation, course and final outcome.
This proposal aims at the improved fundamental understanding of the aforementioned entities, focusing on genotype-phenotype associations, the recognition of new molecular diagnostic and prognostic markers, and on the identification of new therapeutic targets.
All of the above mainly rely on the synthesis and analysis of clinicobiological data from these representative hematologic disorders, using advanced bioinformatics methods.