Understanding mechanisms of clinical aggressiveness and treatment failure in Chronic Lymphocytic Leukemia (CLL) focusing on patients treated with the FCR Regimen: the role of DNA Methylation
Funding Body: Roche S.A.
Service, February 2013- January 2014
Study description: 1] DNA methylation profiling of additional CLL patients relapsing after FCR, with a strong focus on cases carrying del11q and cases with stereotyped B-cell receptors. 2] Gene expression profiling using microarrays in paired samples with pronounced DNA methylation changes at diagnosis and relapse and pathway enrichment analysis of differentially methylated and differentially expressed genes. 3] siRNA screens for hypomethylated and over-expressed genes.