Molecular and functional analysis of Toll-like receptors (TLR) in acute and chronic graft versus host disease (GvHD) after allogenic hematopoietic cell transplantation in patients with hematologic malignancies
Funding Body: Janssen Pharmaceuticals
Sponsorship, March 2014 – September 2015
The development of methodologies that target exclusively the clinical manifestations of Graft vs Host Disease (GvHD) sustaining the desirable activity against the malignant cells of the recipient and the pathogens, could be a crucial intervention in order to improvement of the survival of patients with hematologic malignancies that undergo allogeneic transplantation. In this study, we will investigate the expression of TLR2, TLR4, TLR5, TLR7 and TLR9 at basal level and after activation with their cognate ligands.