Glutathione transferase: multifunctional molecular tools in red and green biotechnology
Funding Body: Ministry of Education
Glutathione transferases (GSTs) are phase II detoxification enzymes that catalyze the conjugation of glutathione (GSH) to xenobiotics and endogenous electrophilic compounds, leading to cellular detoxification. Detailed studies of GSTs are justified because of the considerable interest of these enzymes in agriculture and medicine. Plant GSTs (green biotechnology) attract significant attention as they contribute to defence against oxidative injury during various biotic and abiotic stresses in plants. In medicine (red biotechnology), many anticancer drugs are substrates for human GSTs and, therefore, GSTs are explored as molecular targets for the design of new anticancer drugs against drug-resistant tumours that overexpress GSTs.