Genome wide DNA Methylation studies in lymphoid malignancies

Introduction

DNA methylation is a major epigenetic modification that can affect long-term gene expression without any change in the nucleotide sequence of the DNA. Aberrant DNA methylation is increasingly recognized as relevant for Chronic Lymphocytic Leukemia (CLL) with strong correlations between promoter methylation and transcriptional silencing for critical genes.

Objectives

  • Differential methylation analysis to identify differentially methylated CpG Sites among different subgroups of patients with lymphoid malignancies, especially CLL. Identify the implicated pathways.
  • Evaluate the differences in relation to relapse after treatment per patient and/or groups of patients, based on the genetic profile.